Home » Background » Perivascular Spaces in Disease

Enlarged perivascular spaces (ePVS) have been noted on MRI scans from patients with SVD.

Larger than normal numbers of ePVS have also been associated with several other conditions, including:

  • Cognitive impairment
  • Lacunar stroke
  • Vascular dementia
  • Hypertension
  • Cerebral amyloid angiopathy


ePVS are becoming increasingly recognised as an important marker of brain health, and have the potential to be an imaging biomarker for SVD


Further reading

Read our scientific publications related to enlarged perivascular spaces.  The website links below open in a new window.

Ramirez et al. (2016). Imaging the perivascular space as a potential biomarker of neurovascular and neurodegenerative diseases. Cell Mol Neurobiol. 36(2):289-99 PMID: 26993511

Publication link: www.ncbi.nlm.nih.gov/pubmed/26993511

Potter et al. (2015). Enlarged perivascular spaces and cerebral small vessel disease. Int J Stroke. 10(3):376-81 PMID: 23692610

Publication link: www.ncbi.nlm.nih.gov/pubmed/23692610

Doubal et al. (2010). Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease. Stroke 41(3):450-4 PMID: 20056930

Publication link: www.ncbi.nlm.nih.gov/pubmed/20056930