Publications from network members since the project began
Wardlaw, Smith and Dichgans (2019) Lancet Neurol. Small vessel disease: mechanisms and clinical implications.
Blair et al. (2019) EClinicalMedicine. Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial
Thrippleton et al. (2019). Alzheimer's and Dementia. Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendation
Mutsaerts et al. (2019). Brain. Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study.
Desmarais et al. (2019) J of Neurology, Neurosurgery& Psychiatry. Therapeutic trial design for frontotemporal dementia and related disorders.
Benveniste et al. (2019) Anesth Analg. Glymphatic System Function in Relation to Anesthesia and Sleep States.
Koundal et al. (2019). Neuroscience. Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI.
Zeng et al. (2019). Cell Rep. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice.
Lindekleiv et al. (2019). Stroke. Percutaneous Vascular Interventions Versus Intravenous Thrombolytic Treatment for Acute Ischemic Stroke.
McHutchison et al. (2019) J of Neurology, Neurosurgery& Psychiatry. Functional, cognitive and physical outcomes 3 years after minor lacunar or cortical ischaemic stroke.
Anderson et al. (2019) Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial.
Boido et al. (2019) Nat Commun Mesoscopic and microscopic imaging of sensory responses in the same animal.
Munk et al. (2019) Cell Rep. PDGF-B Is Required for Development of the Glymphatic System.
Ortiz-Ramon et al. (2019). Comput Med Imaging Graph. Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images.
Valdes Hernandez et al. (2019) Int J Mol Sci. Association between Striatal Brain Iron Deposition, Microbleeds and Cognition 1 Year After a Minor Ischaemic Stroke.
Cox et al. (2019) Eur Heart J. Associations between vascular risk factors and brain MRI indices in UK Biobank.
Georgakis et al. (2019) Neurology. WMH and long-term outcomes in ischemic stroke: A systematic review and meta-analysis.
Duchesne et al. (2019) The Canadian Dementia Imaging Protocol: Harmonizing National Cohorts.
Rungta et al. (2019) Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia.
Sagare et al. (2019). Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits.
Thrippleton et al. (2019). MRI Relaxometry for Quantitative Analysis of USPIO Uptake in Cerebral Small Vessel Disease.
Appleton et al. (2019) Effect of Glyceryl Trinitrate on Hemodynamics in Acute Stroke.
Sweeney et al. (2019). Alzheimers Dement. Vascular dysfunction-The disregarded partner of Alzheimer's disease.
Sweeney et al. (2019). Physiol Rev. Blood-Brain Barrier: From Physiology to Disease and Back.
Demiral et al. (2019) Neuroimage. Apparent diffusion coefficient changes in human brain during sleep - Does it inform on the existence of a glymphatic system?
Ramos et al. (2019) Methods Mol Biol. Cisterna Magna Injection in Rats to Study Glymphatic Function.
Rehm et al. (2019) Alzheimers Res Ther. Alcohol use and dementia: a systematic scoping review. PMID: 30611304
Dey et al. (2019). Neurobiol Aging. Cognitive hereterogeneity among community-dwelling older adults with cerebral small vessel disease. PMID: 30875655
Mikhael et al. (2019) Manually-parcellated gyral data accounting for all known anatomical variability.
Davis et al. (2018). Am J Pathol. A Novel Transgenic Rat Model of Robust Cerebral Microvascular Amyloid with Prominent Vasculopathy.
Mestre et al. (2018) Elife. Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
Plog et al. (2018) JCI Insight. Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.
Yu et al. (2018) Transl Stroke Res. Soluble Epoxide Hydrolase-Derived Linoleic Acid Oxylipins in Serum Are Associated with Periventricular White Matter Hyperintensities and Vascular Cognitive Impairment.
Malik et al. (2018) Neurorehabil Neural Repair. Subcortical Brain Involvement Is Associated With Impaired Performance on the Psychomotor Vigilance Task After Minor Stroke.
Bergeron et al. (2018). Ann Neurol. Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.
Mestre et al. (2018) Nat Commun. Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.
Rasmussen, Mestre and Nedergaard (2018). Lancet Neurology. 17(11):1016-1024. The glymphatic pathway in neurological disorders. Access here.
Sweeney et al. (2018) Nat Neurosci. The role of brain vasculature in neurodegenerative disorders.
Alhusaini et al. (2018) Association between carotid atheroma and cerebral cortex structure at age 73 years.
Sapkota et al. (2018) Alzheimers Res Ther Clinical dementia severity associated with ventricular size is differentially moderated by cognitive reserve in men and women.
Elkin et al. (2018) Med Image Comput Comput Assist Interv. GlymphVIS: Visualizing Glymphatic Transport Pathways Using Regularized Optimal Transport.
Madru et al. (2018) Cancer Biother Radiopharm. Simultaneous Preclinical Positron Emission Tomography-Magnetic Resonance Imaging Study of Lymphatic Drainage of Chelator-Free 64Cu-Labeled Nanoparticles.
Pelligrini et al. (2018) Alzheimers Dement. Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review.
Sweeney and Zlokovic (2018). Nature News and Views. 560(7717): 172-174. A lymphatic waste-disposal system implicated in Alzheimer's disease. PMID: 30076374
Zukotynski et al. (2018). AJR Am J Roentgenol. 211(2):246-259. PET/CT of Dementia. PMID: 29949415
Gibson et al. (2018) Post-mortem magnetic resonance imaging in patients with suspected prion disease: Pathological confirmation, sensitivity, specificity and observer reliability. A national registry.
Lipsman et al. (2018) Nat commun. Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound.
Aalling et al. (2018). Curr Neurol Neurosci Rep 18(9):57. Cerebral Metabolic Changes During Sleep. PMID: 30014344
Backhouse et al. (2018) PLoS One. 13(7):e0200525. Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: A systematic review and meta-analysis. PMID: 30011299
Benveniste et al. (2018). Genontology 11:1-14. The glymphatic system and waste clearance with brain aging. PMID: 29996134
Freedman et al. (2018) Alzheimers Res Ther 10(1):65. The Toronto Cognitive Assessment (TorCA): normative data and validation to detect amnestic mild cognitive impairment. PMID: 30021658
Griffin et al. (2018) Blood. 132(2):159-169. Activated protein C, protease activated receptor 1, and neuroprotection. PMID: 29866816
Jian et al (2018) Stroke. Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging. PMID: 30002152
Rajani et al. (2018) Science translational medicine. Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Access here
Wardlaw (2018) Stroke. 49(7):1770-1775. William M. Feinberg Award for Excellence in Clinical Stroke: Small Vessel Disease; a Big Problem, But Fixable. PMID: 29895535
Wiseman et al. (2018) Lupus. 27(8):1329-1337. Cognitive function, disease burden and the structural connectome in systemic lupus erythematosus. PMID: 29722629
Zellner et al. (2018) CADASIL brain vessels show a HTRA1 loss-of-function profile.
Ida et al. (2018) Br J Anaesth 120(6):1245-1254. Protection of cerebral microcirculation, mitochondrial function, and electrocortical activity by small-volume resuscitation with terlipressin in a rat model of harmorrhagic shock. PMID: 29793592
Kisler et al. (2018) Nat Protoc 13(6):1377-1402. In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain. PMID: 29844521
Lam et al. (2018) Sci Rep 8(1):9480. Variability in stroke motor outcome is explained by structural and functional integrity of the motor system. PMID: 29930399
Pottier et al. (2018) Lancet Neurol. 17(6):548-558. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration adn GRN mutations: a genome-wide association study. PMID: 2972492
Bernhardt et al. (2018) Stroke. 49(5):e174-199. Advances in Stroke 2017. PMID: 29669874
Brown et al. (2018) Cardiovasc Res. Understanding the role of the perivascular space in cerebral small vessel disease. PMID: 29726891
Cox et al. (2018) Neurobiol of Aging. Longitudinal serum S100β and brain ageing in the Lothian Birth Cohort 1936.
Fujioka et al. (2018) Ann N Y Acad Sci. The effects of music-supported therapy on motor, cognitive, and psychosocial functions in chronic stroke. PMID: 29797585
Loos et al. (2018) Stroke. 49(5):1183-1188. Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging. PMID: 29567763
Saeed et al. (2018) Alzheimers Dement. APOE-ε4 associates with hippocampal volume, learning, and memort across the spectrum of Alzheimer's disease and dementia with Lewy bodies. PMID: 29782824
Wong et al. (2018) Int J Geriatr Psychiatry. 33(5):729-734. Converting MMSE to MoCA and MoCA 5-minute protocol in an educationally heterogeneous sample with stroke or transient ischemic attack. PMID: 29292529
Xavier et al. (2018) J Vis Exp. Cannula Implantation into the Cisterna Magna of Rodents. PMID: 29889209
Bailey et al. (2018) Clin Sci (Lond). Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. PMID: 29632138
Dawe et al. (2018) J Gerontol A Biol Sci Med Sci. 73(5):636-642. Association Between Quantitative Gait and Balance Measures and Total Daily Physical Activity in Community-Dwelling Older Adults. PMID: 28957994
Horsburgh et al. (2018) Clin Sci (Lond). 132(8):851-868. Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. PMID: 29712883
Lewis et al. (2018). Neuroimage. 176:22-28. Widespread associations between trait conscientiousness and thickness of brain cortical regions. PMID: 29665419
Makaryus et al. (2018) Anesthesiology. Noninvasive Tracking of Anesthesia Neurotoxicity in the Developing Rodent Brain. PMID: 29688900
Ratelade et al. (2018) J Pathol. 244(4):408-420. Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke. PMID: 29266233
Shokri-Kojori et al. (2018) Proc Natl Acad Sci USA 115(17):4483-4488. β-Amyloid accumulation in the human brain after one night of sleep deprivation. PMID: 29632177
Berezuk et al. (2018) Int J Geriatr Psychiatry. 33(3):517-522. Managing money matters: Managing finances is associated with functional independence in MCI. PMID: 29076183
Ferguson et al. (2018) J Stroke Cerebrovasc Dis. Visual Rating Scales of White Matter Hyperintensities and Atrophy: Comparison of Computed Tomography and Magnetic Resonance Imaging. PMID: 29576397
Makin et al. (2017) European Stroke Journal. The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke. Access here
McGrory et al. (2018) Transl Vis Sci Technol. 7(2):12. Towards Standardization of Quantitative Retinal Vascular Parameters: Comparison of SIVA and VAMPIRE Measurements in the Lothian Birth Cohort 1936. PMID: 29600120
Montagne et al. (2018) Nat Med. 24(3):326-337. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. PMID: 29400711
Rodrigues et al. (2018) Lancet Neurol. 17(3):232-240. The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study. PMID: 29331631
Skrobot et al. (2018) Alzheimers Dement. 14(3):280-292. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study. PMID: 29055812
Sweeney et al. (2018) Nat Rev Neurol. 14(3):133-150. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. PMID: 29377008
Wilcox et al. (2018) Intern Med J. Sleep on the ward in intensive care unit survivors: a case series of polysomnography. PMID: 29521453
Ballerini et al. (2018) Sci Rep. 8(1):2132. Perivascular spaces segmentation in brain MRI using optimal 3D filtering. PMID: 29391404
Desmarais et al. (2018). Int Psychogeriatr. 30(2):197-207. Social inappropriateness in neurodegenerative disorders. PMID: 28689508
Jaswal et al. (2018) Neurobiol Aging. 66:23-31. Reduced substantia innominata volume mediates contributions of microvascular and macrovascular disease to cognitive deficits in Alzheimer's disease. PMID: 29505952
Lundgaard et al. (2018) Sci Rep. 8(1):2246. Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. PMID: 29396480
Mortby et al. (2018) Int Psychogeriatr. 30(2):171-175. Dementia clinical trial implications of mild behavioral impairment. PMID: 29448970
Ritchie et al. (2018). Neurobiol Aging. 62:146-158. Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume. PMID: 29149632
Sajic et al. (2018) J Neuroinflammation. 15(1):61. Mitochondrial damage and "plugging" of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation. PMID: 29486771
Santiago et al. (2018) Int J Geriatr Psychiatry. 33(2):279-287. Subcortical hyperintensities in the cholinergic system are associated with improvements in executive function in older adults with coronary artery disease undergoing cardiac rehabilitation. PMID: 28474775
Swardfager et al. (2018). Neurology. 90(8):e673-682. The effect of white matter hyperintensities on verbal memory: Mediation by temporal lobe atrophy. PMID: 29374101
Thrippleton et al.(2018) Int J Stroke. 13(2):195-206. Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing. PMID: 28933655
Wiseman et al. (2018). Hum Brain Mapp. 39(2):622-632. Cognitive abilities, brain white matter hyperintensity volume, and structural network connectivity in older age. PMID: 29139161
Anblagan et al. (2018) Brain Behav. 8(2):e00838. Coupled changes in hippocampal structure and cognitive ability in later life. PMID: 29484252
Arba et al. (2018) Int J Stroke. 13(1):47-56. Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack. PMID: 27543501
Cox et al. (2018) Brain Struct Funct. 223(1):509-518. Brain cortical characteristics of lifetime cognitive ageing. PMID: 28879544
Dickie et al. (2018) Int J Stroke. The brain health index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury. PMID: 29672236
Harper et al. (2018) J Int Med Res. Considerations on accuracy, pattern and possible underlying factors of brain microbleed progression in older adults with absence or mild presence of vascular pathology. PMID: 29578354
Lam et al. (2018) J Neurol Sci. 384:21-29. Neural coupling between contralesional motor and frontoparietal networks correlates with motor ability in individuals with chronic stroke. PMID: 29249372
Middleton et al. (2018) BMC Geriatr. 18(1):27. Centre- versus home-based exercise among people with mci and mild dementia: study protocol for a randomized parallel-group trial. PMID: 29370756
Mutsaerts et al. (2018) J Magn Reson Imaging. 47(1):131-140. Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI). PMID: 28480617
Pinter et al. (2018) Aging 10(1):144-153. Predictors of gait speed and its change over three years in community-dwelling older people. PMID: 29356686
Pinter et al. (2018) J Cereb Blood Flow Metab. Longitudinal MRI dynamics of recent small subcortical infarcts and possible predictors. PMID: 29737904
Plog and Nedergaard (2018) Ann Rev Pathol 13:379-394. The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future. PMID: 29195051
Russin et al. (2018) J Cereb Blood Flow Metab. Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. PMID: 29611451
Sandset et al. (2018) Int J Stroke. Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomized controlled trials of vasoactive drugs in acute stroke: The Blood pressure in Acute Stroke Collaboration, stage-3.
Shi et al. (2018) Clin Sci (Lond). 132(1):157-171. Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review. PMID: 29229867
Smith et al. (2018) Sci Signal. 11(515). Fluorescent Ca2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions. PMID: 29382785
Sun et al. (2018) J Affect Disord. 225:599-606. Global grey matter volume in adult bipolar patients with and without lithium treatment: A meta-analysis. PMID: 28886501
Verkhratsky and Nedergaard (2018) Physiol Rev 98(1):239-389. Physiology of Astroglia. PMID: 29351512
von Holstein-Rathlou et al. (2018) Neurosci Lett. 662:253-258. Voluntary running enhances glymphatic influx in awake behaving, young mice. PMID: 29079431
Benveniste et al. (2017) Anesthesiology 127(6):976-988. Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane. PMID: 28938276
DiNuzzo and Nedergaard (2017) Curr Opin Neurobiol. 47:65-72. Brain energetics during the sleep-wake cycle.PMID: 29024871
Sohail et al. (2017) Mov Disord. 32(12):1729-1737. Sleep fragmentation and Parkinson's disease pathology in older adults without Parkinson's disease. PMID: 29082554
Thrippleton et al. (2017) PLoS One. 12(12):e0189872. Variance components associated with long-echo-time MR spectroscopic imaging in human brain at 1.5T and 3T. PMID: 29287066
Arba et al. (2017). Neurology. 89(21):2143-2150. Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke. PMID: 29070665
Desai and Smith (2017) F100Res. 6:1973. Experimental autoimmune encephalomyelitis from a tissue energy perspective. PMID: 29167741
Gibson et al. (2017) Wellcome Open Res 2:114. Impact of detecting potentially serious incidental findings during multi-modal imaging. PMID: 30009267
Montagne et al. (2017) J Exp Med. 214(11):3151-3169. Alzheimer's disease: A matter of blood-brain barrier dysfunction? PMID: 29061693
Ritchie et al. (2017). Brain Struct Funct. 222(8):3477-3490. Risk and protective factors for structural brain ageing in the eighth decade of life. PMID: 28424895
Swardfager et al. (2017) Neurobiol Aging. Peripheral lipid oxidative stress markers are related to vascular risk factors and subcortical small vessel disease. PMID: 28756941
Abbott et al. (2017) Front Neurol. 8:537. Optimizing the Definitions of Stroke, Transient Ischemic Attack, and Infarction for Research and Application in Clinical Practice. PMID: 29104559
Duncombe et al. (2017) Neuropathol Appl Neurobiol 43(6):477-491. Ageing causes prominent neurovascular dysfunction associated with loss of astrocytic contacts and gliosis. PMID: 28039950
MacPherson et al. (2017) Cortex. 95:92-103. Processing speed and the relationship between Trail Making Test-B performance, cortical thinning and white matter microstructure in older adults. PMID: 28865241
Martinez Sosa and Smith (2017). Clin Sci (Lond). 131(20):2503-2524. Understanding a role for hypoxia in lesion formation and location in the deep and periventricular white matter in small vessel disease and multiple sclerosis. PMID: 29026001
Patel et al. (2017) Neurol Res. 39(10):910-917. Chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis causes selective recognition impairment in adult mice. PMID: 28828966
Roseborough et al. (2017) Alzheimers Dement. 13(10):1154-1167. Associations between amyloid β and white matter hyperintensities: A systematic review. PMID: 28322203
Amar et al. (2017) Neuropharmacology. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. PMID: 28923278
Boulos et al. (2017) Sleep Med. 37:135-140. Restless legs syndrome after high-risk TIA and minor stroke: association with reduced quality of life. PMID: 28899525
Bowles et al. (2017) Neuroimage. Brain lesion segmentation through image synthesis and outlier detection. Access here
Danso et al. (2017) MAPPING: MAnagement and Processing of Images for Population ImagiNG (Fronteirs eBook). Developing an Integrated Image Bank and Metadata for Large-scale Research in Cerebrovascular Disease: Our Experience from the Stroke Image Bank Project. Download here
Dickie et al. (2017) MAPPING: MAnagement and Processing of Images for Population ImagiNG (Fronteirs eBook). 5 Whole Brain Magnetic Resonance Image Atlases: A Systematic Review of Existing Atlases and Caveats for Use in Population Imaging. Download here
Lin and Black (2017) Otol Neurotol. 38(8):e237-239. Linking Deafness and Dementia: Challenges and Opportunities.PMID: 28806332
Loveau et al. (2017) J Clin Invest 127(9):3210-3219. Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. PMID: 28862640
Makin et al. (2017) J Stroke Cerebrovasc Dis. Small Vessel Disease and Dietary Salt Intake: Cross-Sectional Study and Systematic Review. PMID: 28889932
Mutsaerts et al. (2017) J Cereb Blood Flow Metab. 37(9):3184-3192. The spatial coefficient of variation in arterial spin labeling cerebral blood flow images. PMID: 28058975
Oberheim Bush and Nedergaard (2017). Neurochem Res. 42(9):2577-2587. Do Evolutionary Changes in Astrocytes Contribute to the Computational Power of the Hominid Brain? PMID: 28822066
Wardlaw et al. (2017) Neurology 89(10):1003-1010. White matter hyperintensity reduction and outcomes after minor stroke. PMID: 28794252
Callahan et al. (2017) Front Aging Neurosci. 9:260. Adult ADHD: Risk Factor for Dementia or Phenotypic Mimic? PMID: 28824421
Guo et al. (2017) Clin Interv Aging. 12:1251-1270. MRI assessment of whole-brain structural changes in aging. PMID: 28848333
Mestre et al. (2017) Clin Sci 131(17):2257-2274 Perivascular spaces, glymphatic dysfunction, and small vessel disease. PMID: 28798076
Moody et al. (2017) Front Neurosci. 11:467. Maximizing the Potential of Longitudinal Cohorts for Research in Neurodegenerative Diseases: A Community Perspective. PMID: 28912672
Nelson et al. (2017) Proc Natl Acad Sci USA. 114(33):8681-8682. Role of clusterin in the brain vascular clearance of amyloid-ß. PMID: 28765369
Valdes Hernandez et al. (2017) Neuroradiology. Metric to quantify white matter damage on brain magnetic resonance images. PMID: 28815362
Wardlaw et al. (2017) J Cereb Blood Flow Metab 37(8):3042-3052 Carotid disease at age 73 and cognitive change from age 70 to 76 years: A longitudinal cohort study. PMID: 28155579
Windrem et al. (2017) Cell Stem Cell. 21(2):195-208. Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia. PMID: 28736215
Arba et al. (2017) Journal of Stroke and Cerebrovascular Diseases 26(7):1506-1513. Cerebral White Matter Hypoperfusion Increases with Small Vessel Disease Burden. Data from the Third International Stroke Trial. PMID: 28314624
Arba et al. (2017) Acta Neurol Scna. 136(1):72-77. Small vessel disease and clinical outcomes after IV rt-PA treatment. PMID: 28233290
Blair et al. (2017) Current Treatment Options in Cardiovascular Medicine 19(7):56. Advanced Neuroimaging of Cerebral Small Vessel Disease. PMID: 28620783
Cameron et al. (2017) Prog Retin Eye Res 59:131-157. Lateral thinking - Interocular symmetry and asymmetry in neurovascular patterning, in health and disease. PMID: 28457789
Kisler et al. (2017) Nat Rev Neurosci. 18(7):419-434. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. PMID: 28515434
Mcgrory et al. (2017) Br J Opthalmol. 101(7):993-998. Retinal microvascular network geometry and cognitive abilities in community-dwelling older people: The Lothian Birth Cohort 1936 study. PMID: 28400371
McHutchison et al. (2017) Epidemiology 28(4):608-618. Education, Socioeconomic Status, and Intelligence in Childhood and Stroke Risk in Later Life: A Meta-analysis. PMID: 28410350 A video explaining this research can be accessed here
Nestor et al. (2017) Alzheimers Dement 13(7):749-760. Small vessel disease is linked to disrupted structural network covariance in Alzheimer's disease. PMID: 28137552
Netto et al. (2017) Neurosurgery. Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol. PMID: 28973554
Shirzadi et al. (2017) J Magn Reson Imaging. Enhancement of automated blood flow estimates (ENABLE) from arterial spin-labeled MRI. PMID: 28681479
Valdés Hernández et al. (2017) Front. Neurol. Application of Texture Analysis to Study Small Vessel Disease and Blood-Brain Barrier Integrity. Access here
van Veluw et al. (2017) Lancet Neurology. Detection, risk factors and functional consequences of cerebral microinfarcts. PMID: 28716371
Wilcox et al. (2017) BMJ open. 7(7):e015600. A study protocol for an observational cohort investigating COGnitive outcomes and WELLness in survivors of critical illness: the COGWELL study. PMID: 28710215
Zhao and Zlokovic (2017) Cell. Res. 27(7):849-850. Remote control of BBB: A tale of exosomes and microRNA. PMID: 28674430
Cronin et al. (2017). Alz Dementia. 13(6):689-700. Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1. PMID: 27883893
Edwards et al. (2017) J Alzheimers Dis 59(3):1113-1122. Antihypertensive Treatment is associated with MRI-Derived Markers of Neurodegeneration and Impaired Cognition: A Propensity-Weighted Cohort Study. PMID: 28731439
González-Castro et al. (2017) Clin Sci 131(13):1465-1481. Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance PMID: 28468952
Kjaerby et al. (2017) Neurochem Res. 42(6):1810-1822. Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function? PMID: 28210958
Lee et al. (2017) Magn Reson Med. Quantative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T. PMID: 28627037
Lundgaard et al. (2017) J Cereb Blood Flow Metab 37(6):2112-2124. Glymphatic clearance controls state-dependent changes in brain lactate concentration. PMID: 27481936
Robertson et al. (2017) AJNR Am J Neuroradiol. Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity. PMID: 28619834
Shenkin et al. (2017) Neuroimage 153:399-409. Improving data availability for brain image biobanking in healthy subjects: Practice-based suggestions from an international multidisciplinary working group. PMID: 28232121
Stamenova et al. (2017) Cortex. 91:316-326. The effect of focal cortical frontal and posterior lesions on recollection and familiarity in recognition memory. PMID: 28499557
Wardlaw et al. (2017) Alzheimer's and Dementia 13(6):634-643. Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study. Access here
Lam et al. (2017) Alzheimers Dement. 13(5):520-530. Characterizing familial corticobasal syndrome due to Alzheimer's disease pathology and PSEN1 mutations.PMID: 27743520
Lin et al. (2017) Laryngoscope. 127 Suppl 1:S4-S11. Development of cognitive screening test for the severely hearing impaired: Hearing-impaired MoCA. PMID: 28409842
Meng et al. (2017) Ann Neurol. 81(5):611-617. Focused ultrasound as a novel strategy for Alzheimer disease therapeutics. PMID: 28395123
Montero-Odasso et al. (2017) J Alz Dis. 59(2):707-721. Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI). PMID: 28671116
Mutsaerts et al. (2017) J Magn reson Imaging. Comparison of arterial spin labeling registration strategies in the multi-centre GENetic frontotemporal dementia initiative (GENFI). PMID: 28480617
Ochocinska et al. (2017) Fluids Barriers CNS. 14(1):12. NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface. PMID: 28457227
Ratner et al. (2017) Neuroimage 152:530-537. Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport. PMID: 28323163
Smith et al. (2017). J Am Heart Assoc. 6(5). Therapeutic Strategies and Drug Development for Vascular Cognitive Impairment. PMID: 28476873
Wiseman et al. (2017) Lupus 26(6):588-597. Fatigue and cognitive function in systemic lupus erythematosus: associations with white matter microstructural damage. A diffusion tensor MRI study and meta-analysis. PMID: 27687026
Cole et al. (2017) Mol Psychiatry. Brain age predicts mortality. PMID: 28439103
Cox et al. (2017) Psychoneuroendocrinology 78:151-158. Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men. PMID: 28199858
Jiang et al. (2017) J Cereb Blood Flow Metab. 37(4):1326-1337. Impairment of the glymphatic system after diabetes. PMID: 27306755
Joutel and Chabriat (2017) Clin Sci. 131(8):635-651. Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms. PMID: 28351960
Keith et al. (2017) J Neuropathol Exp Neurol. 76(4):299-312. Collagenosis of the Deep Medullary Veins: An Underrecognised Pathologic Correlate of White Matter Hyperintensities and Periventricular Infarction? PMID: 28431180
Lim et al. (2017) Nat Commun. 8:14931. Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer's disease. PMID: 28368004
McKenzie et al. (2017) Sci Rep. 7:45567. Validation of a smartphone-based EEG among people with epilepsy: A prospective study. PMID: 28367974
Nikolakopoulou et al. (2017) PLoS One Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signalling. PMID: 28441414
Sun et al. (2017) J Neurosci. 37(17):4493-4507. SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions. PMID: 28336567
Valdes Hernandez et al. (2017). Neurobiol Aging. 52:1-11. Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936. PMID: 28104542
Backhouse et al. (2017) Neurology. 88(10):976-984. Early life risk factors for cerebrovascular disease: A systematic review and meta-analysis. PMID: 28188307
Berezuk et al. (2017) J Alz Dis. 58(2):425-434. Functional Reserve: Experience Participating in Instrumental Activities of Daily Living is Associated with Gender and Functional Independence in Mild Cognitive Impairment. PMID: 28453478
Boulos et al. (2017) Sleep. 40(3). Periodic Limb Movements and White Matter Hyperintensities in First-Ever Minor Stroke or High-Risk Transient Ischemic Attack. PMID: 28329254
de Leon et al. (2017) J Nucl Med. CSF clearance in Alzheimer Disease measured with dynamic PET. PMID: 28302766
Kisler et al. (2017) Nat Neurosci. 20(3):406-416. Pericyte degeneration leads to neurovascular uncoupling and limites oxygen supply to brain. PMID: 28135240
Marcotte et al. (2017). Dement Geriatr Cogn Dis Extra. 7(1):52-73. White Matter Disruption and Connected Speech in Non-Fluent and Semantic Variants of Primary Progressive Aphasia. PMID: 28611820
Pettersen et al. (2017) Neurology 88(11):1077-1080. CADASIL accelerated by acute hypotension: Arterial and venous contribution to leukoaraiosis. PMID: 28202707
Wang et al. (2017) J Neurosci. 37(11):2870-2877. Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts. PMID: 28188218
Benveniste et al. (2017) J Clin Invest. 127(2):447-449. Seeing how we smell. PMID: 28112677
Cotrina et al. (2017) Neuroscience 343:483-494. Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke. PMID: 28003156
Chappell et al. (2017) Trials 18(1):78. Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study. PMID: 28222778
Mair et al. (2017) Stroke. 48(2):353-360. Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke. PMID: 28008093
Muñoz Maniega et al. (2017) J Cereb Blood Flow Metab 37(2):644-656 Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease. PMID: 26933133
Van der Putten et al. (2017) Physiol Meas. 38(2):205-218. A multispectral microscope for in vivo oximetry of rat dorsal spinal cord vasculature. PMID: 28001129
Benveniste et al. (2017) Neuroscientist. The Glymphatic Pathway. PMID: 28466758
Blair et al. (2017) Int J Stroke. Preventing cognitive decline and dementia from cerebral small vessel disease: the laci-1 trial. Protocol and statistical analysis plan f a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination. PMID: 28906205
Boulos et al. (2017) J Stroke Cerebrovasc Dis. 26(1):143-149. Unattended Hospital and Home Sleep Apnea Testing Following Cerebrovascular Events. PMID: 27717683
Dickie et al. (2017) Int J Stroke. Blood pressure variability and leukoaraiosis in acute ischemic stroke. PMID: 28872448
Job et al. (2017) Neuroimage. 144(PtB):299-304. A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS). PMID: 26794641
Liu et al.,(2017) J Cereb Blood Flow Metab. Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum. PMID: 29192539
Loos et al. (2017) Int J Stroke. The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke. PMID: 28906203
Pinter et al. (2017) Sci Rep. Impact of small vessel disease in the brain on gait and balance. PMID: 28134332
Rungta et al. (2017) Nat Commun. Light controls cerebral blood flow in naive animals. PMID: 28139643
Swardfager et al. (2017) Alzheimers Dement 7:56-60. Peripheral inflammatory markers indicate microstructural damage within periventricular white matter hyperintensities in Alzheimer's disease: A preliminary report. PMID: 28275700
Thrippleton et al. (2017) Int J Stroke. Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing. PMID: 28933655