Home » Related Publications

Publications related to small vessel disease

Website links listed below open in a new window.

2022


August

Zheng et al (2022) The association of enlarged perivascular space with microglia-related inflammation and Alzheimer's pathology in cognitively normal elderly

Sun et al (2022) Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Adults with Moyamoya Disease

Ball et al (2022) Predictors of post-stroke cognitive impairment using acute structural MRI neuroimaging: A systematic review and meta-analysis

 

July

Pinheiro et al (2022) Association of Apolipoprotein E ɛ4 Allele with Enlarged Perivascular Spaces

Kuipers et al (2022) A cluster of blood-based protein biomarkers reflecting coagulation relates to the burden of cerebral small vessel disease

Wang et al (2022) Severity of Intracranial Large Artery Disease Correlates With Cerebral Small Vessel Disease

Xu et al (2022) Glymphatic dysfunction correlates with severity of small vessel disease and cognitive impairment in cerebral amyloid angiopathy

 

June

Xuan et al (2022) Glymphatic System: Emerging Therapeutic Target for Neurological Diseases

Mendes & Velloso (2022) Perivascular macrophages in high-fat diet-induced hypothalamic inflammation

Yan et al (2022) Peripheral monocyte-derived cells counter amyloid plaque pathogenesis in a mouse model of Alzheimer's disease

Mildenberger et al (2022) Diversity and function of brain-associated macrophages

Ibitoye et al (2022) A link between frontal white matter integrity and dizziness in cerebral small vessel disease

Kaczynski et al (2022) 18 F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome

Duplaa et al (2022) Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate

 

May

Gao et al (2022) The Association of Nocturnal Blood Pressure Patterns and Other Influencing Factors With Lacunes and Enlarged Perivascular Spaces in Hypertensive Patients

Neumann et al (2022) Microvascular Impairment in Patients With Cerebral Small Vessel Disease Assessed With Arterial Spin Labeling Magnetic Resonance Imaging: A Pilot Study

Lao et al (2022) Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer's continuum

Yu et al (2022) Perivascular Spaces, Glymphatic System and MR

Mahammedi et al (2022) Small Vessel Disease, a Marker of Brain Health: What the Radiologist Needs to Know

 

April

Fu et al (2022) Fundus Changes Evaluated by OCTA in Patients With Cerebral Small Vessel Disease and Their Correlations: A Cross-Sectional Study

Cheng et al (2022) Cerebral small vessel disease and prognosis in intracerebral haemorrhage: A systematic review and meta-analysis of cohort studies

Seki et al (2022) Neuropsychological Profile of Early Cognitive Impairment in Cerebral Small Vessel Disease

 

March 

Tao et al (2022) Dihydromyricetin ameliorates oxygen‑glucose deprivation and re‑oxygenation‑induced injury in HT22 cells by activating the Wnt/β‑catenin signaling pathway link

 

February

Collins-Yoder & Key (2022) Acute ischemic stroke or migraine with aura? Triage considerations link

 

January 

Jiang et al (2022 Longitudinal white matter hyperintensity changes and cognitive decline in patients with minor stroke link 

Olsen & Andersen (2022) Absolute risk of ischemic and hemorrhagic stroke in Danish women using oral contraceptives link

Shen et al (2022) Prediction of Mechanosensitive Genes in Vascular Endothelial Cells Under High Wall Shear Stress link

Yusuf et al (2022) Roles of Polymorphonuclear Neutrophils in Ischemic Brain Injury and Post-Ischemic Brain Remodeling link

Zhang et al (2022) Evaluation and Prediction of Post-stroke Cerebral Edema Based on Neuroimaging link

Koton et al (2022) Association of Ischemic Stroke Incidence, Severity, and Recurrence With Dementia in the Atherosclerosis Risk in Communities Cohort Study link

 

 

2021


December

Cui et al (2021) Risk of ischemic stroke in patients with COVID-19 infection: A systematic review and meta-analysis link

Xie et al (2022) Nomogram to Predict Symptomatic Intracranial Hemorrhage after Intravenous Thrombolysis in Acute Ischemic Stroke in Asian Population link

 

November

Moullaali et al (2021) Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data link

Zhang et al (2021) MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure link

Wang et al (2021) Severity of Intracranial Large Artery Disease Correlates With Cerebral Small Vessel Disease link

Kim et al (2021) Cilostazol Versus Aspirin on White Matter Changes in Cerebral Small Vessel Disease: A Randomized Controlled Trial link

Inkeri et al (2021) Glycemic control is not related to cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes link

Lee et al (2021) Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease link

Jiang et al (2021) Association of Serum Interleukin-34 and Insulin Resistance with Cognitive Impairment in Patients with Cerebral Small Vessel Disease link

 

October 

de Havenon et al (2021) Cilostazol for Secondary Stroke Prevention: History, Evidence, Limitations, and Possibilities link

Luu et al (2021) The impact of reporting magnetic resonance imaging incidental findings in the Canadian alliance for healthy hearts and minds cohort link

teng et al (2021) Long-Term Use of Metformin Is Associated With Reduced Risk of Cognitive Impairment With Alleviation of Cerebral Small Vessel Disease Burden in Patients With Type 2 Diabetes link

Hautecloque et al (2021) Multifocal and Microvascular Involvement in Ischemic Stroke During COVID-19: A Cohort Study With Comparison With Non-COVID-19 Stroke link

Xu et al (2021) A Novel Imaging Biomarker for Cerebral Small Vessel Disease Associated With Cognitive Impairment: The Deep-Medullary-Veins Score link

 

September

Vynckier et al (2021) Phenotypes of Chronic Covert Brain Infarction in Patients With First-Ever Ischemic Stroke: A Cohort Study link

Ball et al (2021) Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review and meta-analysis link

Shi et al (2021) Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals link

Al-Shahi Salman et al (2021) Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage: Extended Follow-up of the RESTART Randomized Clinical Trial link

SoSTART Collaboration (2021) Effects of oral anticoagulation for atrial fibrillation after spontaneous intracranial haemorrhage in the UK: a randomised, open-label, assessor-masked, pilot-phase, non-inferiority trial Link

Lu et al (2021) The protective effect of harpagoside on angiotensin II (Ang II)-induced blood-brain barrier leakage in vitro link

Simonsen et al (2021) Sleep-disordered breathing and cerebral small vessel disease-acute and 6 months after ischemic stroke link

Nam et al (2021) Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer link

Kuuluvainen et al (2021) COL4A1 and COL4A2 Duplication Causes Cerebral Small Vessel Disease With Recurrent Early Onset Ischemic Strokes link

 

August

Xia et al (2021) Early decompressive hemicraniectomy in thrombolyzed acute ischemic stroke patients from the international ENCHANTED trial link

Boulestreau et al (2021) Neurologically asymptomatic patients frequently present cerebral injuries during malignant hypertension: a MRI study link

Zhang et al (2021) Direct endovascular treatment versus bridging therapy in patients with acute ischemic stroke eligible for intravenous thrombolysis: systematic review and meta-analysis link

Takahashi et al (2021) Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke link

Safayet et al (2021) Melatonin and Sleep Disturbances in Alzheimer's Disease link

Guan et al (2021) Neuroimaging Anomalies in Community-Dwelling Asymptomatic Adults With Very Early-Stage White Matter Hyperintensity link

 

July 

No authors listed (2021) Correction to: 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association Link

Du et al (2021) Multi-Dimensional Diffusion Tensor Imaging Biomarkers for Cognitive Decline From the Preclinical Stage: A Study of Post-stroke Small Vessel Disease link

Muino et al (2021) Contribution of "Omic" Studies to the Understanding of Cadasil. A Systematic Review link

Hu et al (2021) NOTCH3 Variants and Genotype-Phenotype Features in Chinese CADASIL Patients link

Gravestejn et al (2021) NOTCH3 variant position is associated with NOTCH3 aggregation load in CADASIL vasculature link

 

June 

Yu et al (2021) Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging link

Prasad et al (2021) Cohort profile: The LoCARPoN—a population-based prospective cohort study in middle-aged and older adults in India Link

Zhou et al (2021) Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure target. Link

Portilla-Fernandez et al (2021) Meta-analysis of epigenome-wide association studies of carotid intima-media thickness. Link

Pilotto et al (2021) Association of Orthostatic Hypotension With Cerebral Atrophy in Patients With Lewy Body Disorders Link

Che Mohd Nassir et al (2021) COVID-19 Infection and Circulating Microparticles-Reviewing Evidence as Microthrombogenic Risk Factor for Cerebral Small Vessel Disease Link

Funck et al (2021) Arterial stiffness and progression of cerebral white matter hyperintensities in patients with type 2 diabetes and matched controls: a 5-year cohort study Link

El Nahas et al (2021) Borderzone Infarction and Small Vessel Disease in a Sample of Egyptian Stroke Patients: Differences and Similarities Link

Pan et al (2021) Hypoxia-inducible factor-1: regulatory mechanisms and drug development in stroke Link

 

May

Humpreys et al (2021) Correlations in post-mortem imaging-histopathology studies of sporadic human cerebral small vessel disease: A systematic review. Link

Hachinski et al (2021) A new definition of brain health. Link

Walsh et al (2021) Microglial activation and blood-brain barrier permeability in cerebral small vessel disease. Link

Chen et al (2021) Acute lacunar infarct in an obese adolescent with obstructive sleep apnea. Link

Tsai et al (2021) Variations of risk factors for ischemic stroke and its subtypes in Chinese patients in Taiwan. Link

Sangalli et al (2021) Impact of SARS-CoV-2 infection on acute intracerebral haemorrhage in northern Italy. Link 

Jiang et al (2021) Advances in Understanding the Pathogenesis of Lacunar Stroke: From Pathology and Pathophysiology to Neuroimaging. Link

Wu et al (2021) Edaravone attenuates H 2 O 2 or glutamate-induced toxicity in hippocampal neurons and improves AlCl 3/D-galactose induced cognitive impairment in mice. Link

Wang et al (2021) STC1 ameliorates cognitive impairment and neuroinflammation of Alzheimer's disease mice via inhibition of ERK1/2 pathway. Link

Chevalley et al (2021) Socio-environmental predictive factors for discharge destination after inpatient rehabilitation in patients with stroke: a systematic review and meta-analysis. Link

Cataldo et al (2021) Cortical inflammation and brain signs of high-risk atherosclerosis in a non-human primate model. Link

 

April

Kapadia et al (2021) In vivo detection of beta-amyloid at the nasal cavity and other skull-base sites: a retrospective evaluation of ADNI1/GO. Link

Sagnier et al (2021) Severity of Small Vessel Disease Biomarkers Reduces the Magnitude of Cognitive Recovery after Ischemic Stroke Link

Brutto et al (2021) Dietary Oily Fish Intake is Inversely Associated with Severity of White Matter Hyperintensities of Presumed Vascular Origin. A Population-Based Study in Frequent Fish Consumers of Amerindian Ancestry. Link

Jiaerken et al (2021) Dilated perivascular space is related to reduced free-water in surrounding white matter among healthy adults and elderlies but not in patients with severe cerebral small vessel disease. Link

Hausman-Kedem et al (2021) Deletion in COL4A2 is associated with a three-generation variable phenotype: from fetal to adult manifestations. Link

Vinke et al (2021) Intracranial arteriosclerosis is related to cerebral small vessel disease: a prospective cohort study. Link

Zhang et al (2021) Deep Fusion of Brain Structure-Function in Mild Cognitive Impairment. Link

 

March 

Rotta et al (2021) Detection of Cerebral Microbleeds With Venous Connection at 7 Tesla MRI Link

Dennis et al (2021) Sex Differences in Stroke Hospitalization Incidence, 30-Day Mortality, and Readmission in a Regional Medical Center in the Southwestern United States Link

Manera et al (2021) MRI data-driven algorithm for the diagnosis of behavioural variant frontotemporal dementia Publication link

Chia et al (2021) Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Link

Lyden et al (2021) Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation Link

Chojdak-Łukasiewicz et al (2021) Cerebral small vessel disease: A review. Link

Kerkhofs et al (2021) Baseline Blood-Brain Barrier Leakage and Longitudinal Microstructural Tissue Damage in the Periphery of White Matter Hyperintensities Link

Kwan et al (2021) Cognitive Impairment after Lacunar Stroke and the Risk of Recurrent Stroke and Death Link

Chen et al (2021) Research progress of imaging technologies for ischemic cerebrovascular diseases Link

Ilinca et al (2021) MAP3K6 Mutations in a Neurovascular Disease Causing Stroke, Cognitive Impairment, and Tremor Link

 

February 

Zhou et al (2021) Low- versus standard-dose alteplase in acute lacunar ischemic stroke: The ENCHANTED Trial Link

Bernal M et al (2021) Differential Characteristics of Ischemic and Hemorrhagic Stroke in Patients with Cerebral Small Vessel Disease Link

Guo et al (2021) Increased insulin resistance is associated with vascular cognitive impairment in Chinese patients with cerebral small vessel disease Link

Karaszewski et al (2021) Efficacy and Safety of Intravenous rtPA in Ischemic Strokes Due to Small-Vessel Occlusion: Systematic Review and Meta-Analysis Link

Geraets et al (2021) The relation of depression with structural brain abnormalities and cognitive functioning: the Maastricht study Link

Huang et al (2021) White Matter Free Water is a Composite Marker of Cerebral Small Vessel Degeneration Link

Leowenstein & Rabbat (2021) Neurological complications of systemic hypertension Link

Pieruccini-Faria et al (2021) Gait variability across neurodegenerative and cognitive disorders: Results from the Canadian Consortium of Neurodegeneration in Aging (CCNA) and the Gait and Brain Study. Link

 

January

Saba et al (2021) Multinational Survey of Current Practice from Imaging to Treatment of Atherosclerotic Carotid Stenosis Link 

Zheng et al (2021). GRP per capita and hospital characteristics associated with intravenous tissue plasminogen activator adherence rate: evidence from the Chinese Stroke Center Alliance. Link

Kim et al (2021). Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion. Link

Chen et al (2021). Association of neuroimaging markers of cerebral small vessel disease with short-term outcomes in patients with minor cerebrovascular events. Link

Kim et al (2021). Association of Bone Mineral Density to Cerebral Small Vessel Disease Burden. Link

Bontzos et al (2021). Retinal neurodegeneration, macular circulation and morphology of the foveal avascular zone in diabetic patients: quantitative cross-sectional study using OCT-A Link

Saji et al (2021). The Association between Cerebral Small Vessel Disease and the Gut Microbiome: A Cross-Sectional Analysis. Link

Smith et al (2021) Vascular Contributions to Neurodegeneration: Protocol of the COMPASS-ND Study

 

2020


December

Liu et al (2021) Intracranial Atherosclerosis Coexisting With White Matter Hyperintensities May Predict Unfavorable Functional Outcome in Patients With Acute Cerebral Ischemia Link

Tayler et al (2021) Mediators of cerebral hypoperfusion and blood-brain barrier leakiness in alzheimer's disease, vascular dementia and mixed dementia. Link

Bijkerk et al (2021) Circulating angiopoietin-2 and angiogenic microRNAs associate with cerebral small vessel disease and cognitive decline in older patients reaching end stage renal disease Link

Waller et al (2021) Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to alzheimer's and small vessel disease pathologies Link

Delcourt et al (2021) Brain imaging abnormalities and outcome after acute ischaemic stroke: the ENCHANTED trial Link 

 

November 

Papanastasiou et al (2020) Pharmacokinetic modelling for the simultaneous assessment of perfusion and 18 F-flutemetamol uptake in cerebral amyloid angiopathy using a reduced PET-MR acquisition time: proof of concept Link

Beishon et al (2020) Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial Link

Rodriques et al (2020) The association between CT biomarkers of cerebral small vessel diseases and long-term outcome after spontaneous intracerebral hemorrhage Link

Camarda et al (2020) APOE Genotypes and Brain Imaging Classes in Normal Cognition, Mild Cognitive Impairment, and Alzheimer's Disease: a Longitudinal Study Link

Annus et al (2020) Connection between small vessel disease related stroke and the MTHFR C677T polymorphism in a Hungarian population Link

 

October

Blenvis et al (2020) Brain arteriolosclerosis Link

Wu et al (2020) Intracranial Arterial Calcification Relates to Long-Term Risk of Recurrent Stroke and Post-stroke Mortality Link

Hansen et al (2020) Relationship of White Matter Lesions with Intracerebral Hemorrhage Expansion and Functional Outcome: MISTIE II and CLEAR III Link

Mair et al (2020) Feasibility and diagnostic accuracy of using brain attenuation changes on CT to estimate time of ischemic stroke onset Link

Delcourt et al (2020) Brain imaging abnormalities and outcome after acute ischaemic stroke: the ENCHANTED trial Link

Muir (2020) Prognostic value of acute CT in stroke thrombolysis Link

Colelli et al (2020) Feasibility of unattended home sleep apnea testing in a cognitively impaired clinic population Link

Ganesh et al (2020) Trial of remote ischaemic preconditioning in vascular cognitive impairment (TRIC-VCI): protocol Link

Franzmeier et al (2020) Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration Link

 

September 

Zhang et al (2020) Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture Link

Umemura et al (2020) Oral anticoagulant use and the development of new cerebral microbleeds in cardioembolic stroke patients with atrial fibrillation Link

You et al (2020) Plasma lipidomic analysis of sphingolipids in patients with large artery atherosclerosis cerebrovascular disease and cerebral small vessel disease Link 

Imam et al (2020) Stroke in the adult Qatari population (Q-stroke) a hospital-based retrospective cohort study Link

Pålhaugen et al (2020) Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns Link

Brutto et al (2020) Dawson Fingers in Older Adults with Cerebral Small Vessel Disease: A Population Study Link

Pan et al (2020) Brain structural changes in CADASIL patients: A morphometric magnetic resonance imaging study Link

Moreton et al (2020) Brain imaging factors associated with progression of subcortical hyperintensities in CADASIL over two year follow up Link

Liu et al (2020) Uncontrolled hypertension associates with subclinical cerebrovascular health globally: a multimodal imaging study Link

Varkanitsa et al (2020) White Matter Hyperintensities Predict Response to Language Treatment in Poststroke Aphasia Link

Jaworek et al (2020) Exome Array Analysis of Early-Onset Ischemic Stroke Link

Wong et al (2020) Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment Link

Knol et al (2020) Association of common genetic variants with brain microbleeds: A Genome-wide Association Study Link

Kneihsl et al (2020) Intracranial Pulsatility in Relation to Severity and Progression of Cerebral White Matter Hyperintensities Link

Pasi et al (2020) Long-term mortality in survivors of spontaneous intracerebral hemorrhage Link

Giannetto et al (2020) Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice Link

 

August 

Sliz et al (2020) Thickness of the cerebral cortex shows positive association with blood levels of triacylglycerols carrying 18-carbon fatty acids Link

Wu et al (2020) Relationships between memory decline and the use of metformin or DPP4 inhibitors in people with type 2 diabetes with normal cognition or Alzheimer's disease, and the role APOE carrier status Link

Mok et al (2020) Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future Link

Porcu et al (2020) Extracranial Carotid Artery Stenosis: The Effects on Brain and Cognition with a Focus on Resting-State Functional Connectivity Link

Anagnostou et al (2020) Bedside Assessment of Vergence in Stroke Patients Link

Liao et al (2020) Mitochondrial DNA m.3243A>G mutation rarely causes CADASIL-like phenotype Link

Rannikmäe et al (2020) Beyond the Brain: Systematic Review of Extracerebral Phenotypes Associated With Monogenic Cerebral Small Vessel Disease Link 

 

July

Stæger et al (2020) A three-dimensional, population-based average of the C57BL/6 mouse brain from DAPI-stained coronal slices Link

Kwong et al (2020) Twists and turns of ocular glymphatic clearance – new study reveals surprising findings in glaucoma Link

Arrelanes et al (2020) Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial Link

Mukherjee et al (2020) 3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase Link

Ohene et al (2020) Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE ASL MRI Link

 

June

Varatharaj et al (2020) Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study Link

Anad et al (2020) Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease Link

Zukotynski et al (2020) The Use of Random Forests to Identify Brain Regions on Amyloid and FDG PET Associated With MoCA Score Link

 

May 

Larsen et al (2020) Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep Link

Olsen et al (2020) Peripheral Electrical Stimulation Paired With Movement-Related Cortical Potentials Improves Isometric Muscle Strength and Voluntary Activation Following Stroke Link 

 

March

Ratelade et al (2020) Reducing Hypermuscularization of the Transitional Segment between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage. Link

Lazic et al (2020) Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease Link

Olama et al (2020) Simple MRI score aids prediction of dementia in cerebral small vessel disease. Link

He et al. (2020) Homozygous NOTCH3 p.R587C mutation in Chinese patients with CADASIL: a case report. Link

Grasby et al (2020) The genetic architecture of the human cerebral cortex. Link

Nagaraja et al (2020) Reversible diffusion-weighted imaging lesions in acute ischemic stroke Link

Zhu et al (2020) Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy Link

 

February 

Harris et al (2020) Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age Link

Biton et al (2020) Polygenic Architecture of Human Neuroanatomical Diversity Link 

Wang et al. (2020) Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease. Link

Robalo et al. (2020) Effect of fixed-density thresholding on structural brain networks: a demonstration in cerebral small vessel disease. Link

van Veluw et al. (2020) Editorial: Cerebral Small Vessel Diseases: From Vessel Alterations to Cortical Parenchymal Injury Link

Contreras et al (2020) Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-α in APOE4 carriers Link

Hauglund et al. (2020). Meningeal lymphangiogenesis and enhanced glymphatic activity in mice with chronically implanted EEG electrodes Link

Hussein et al. (2020). The association between resting‐state functional magnetic resonance imaging and aortic pulse‐wave velocity in healthy adults. Link

Garnier-Crussard et al. (2020) White matter hyper-intensities in ageing: Pathophysiology, associated cognitive disorders and prevention Link

Vernooij & Buchem (2020) Neuroimaging in Dementia. Link

Yuan et al. (2020) Single nucleotide polymorphism of MTHFR rs1801133 associated with elevated Hcy levels affects susceptibility to cerebral small vessel disease. Link

Liu et al. (2020) Fiber Connectivity Density in Cerebral Small-Vessel Disease Patients With Mild Cognitive Impairment and Cerebral Small-Vessel Disease Patients With Normal Cognition. Link

Yatawara et al. (2020) The role of cerebral microbleeds in the incidence of post-stroke dementia. Link

Suzuyama et al. (2020) Total small vessel disease score and cerebro-cardiovascular events in healthy adults: The Kashima scan study. Link

Zheng et al. (2020) Thrombolysis with alteplase 3–4.5 hours after acute ischaemic stroke: the first multicentre, phase III trial in China Link

 

January

Lemmens et al. (2020) Systematic Review on Fractal Dimension of the Retinal Vasculature in Neurodegeneration and Stroke: Assessment of a Potential Biomarker. Link

Dawe et al. (2020) Late-life cognitive decline is associated with hippocampal volume, above and beyond its associations with traditional neuropathologic indices Link

Zhai et al.(2020) Dexmedetomidine Post-Conditioning Alleviates Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting High Mobility Group Protein B1 Group (HMGB1)/Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling Pathway Link

Caldwell et al. (2020) Evidence for temperature-mediated regional increases in cerebral blood flow during exercise Link

Holmsquist et al.  (2020) The association of depression with subsequent dementia diagnosis: A Swedish nationwide cohort study from 1964 to 2016 Link

Wouts et al. (2020) Empirical support for the vascular apathy hypothesis: A structured review Link

Zhu et al. (2020) Reduced Levels of Cerebrospinal Fluid/Plasma Aβ40 as an Early Biomarker for Cerebral Amyloid Angiopathy in RTg-DI Rats Link

Ge et al. (2020) Analysis of young ischemic stroke patients in northeast China. Link

Moodie et al (2020) Fluctuating asymmetry in brain structure and general intelligence in 73-year-olds Link 

 

2019


December

Zhou et al. (2019) Irregular surface of carotid atherosclerotic plaque is associated with ischemic stroke: a magnetic resonance imaging study Link

Xu et al. (2019) Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis Link

Han et al. (2019) A Comparison Study of Cilostazol and Aspirin on Changes in Volume of Cerebral Small Vessel Disease White Matter Changes: Protocol of a Multicenter, Randomized Controlled Trial Link

Neves et al (2019) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL Link

 

November

Fultz et. al. (2019) Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep Link

Grifin el.al. (2019) Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury. Link

Liang et.al. (2019) Cerebral Small Vessel Disease Burden Is Associated With Accelerated Poststroke Cognitive Decline: A 1-Year Follow-Up Study. Link

Lo et. al. (2019) Profile of and risk factors for poststroke cognitive impairment in diverse ethno-regional groups. Link

Qu et.al. (2019) Preexisting Cerebral Abnormalities and Functional Outcomes After Acute Ischemic Stroke. Link

Wang et.al. (2019) Understanding the association between psychomotor processing speed and white matter hyperintensity: A comprehensive multi-modality MR imaging study. Link

Huang et. al. (2019) Association of obstructive sleep apnea and cerebral small vessel disease: a systematic review and meta-analysis Link

 

October

Chung et al (2019) Genome-wide association study of cerebral small vessel disease reveals established and novel loci. Link

Denver et. al. (2019) A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer’s Disease Link

Dobrynina et.al. (2019) Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease. Link

Goldstein et.al. (2019) Cerebral Small Vessel Disease Burden and All-Cause Mortality: Mayo Clinic Florida Familial Cerebrovascular Diseases Registry. Link

Raz et.al. (2019) Possible Empirical Evidence of Glymphatic System on CT after Endovascular Perforations. Link

Villeneuve S (2019) Lifespan Cognitive Reserve—A Secret to Coping With Neurodegenerative Pathology. Link

Neves et al. (2020) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL

 

September

Brutto et.al. (2019) Effect of Heart Rate Variability on the Association Between the Apnea-Hypopnea Index and Cerebral Small Vessel Disease. Link

Duperron et.al. (2019) High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage. Link

Faraco et.al. (2019) Dietary salt promotes cognitive impairment through tau phosphorylation. PDF

 

August

Hernández-Díaz et.al. (2019) Cerebral Small Vessel Disease Associated with Subclinical Vascular Damage Indicators in Asymptomatic Hypertensive Patients. Link

Huo et. al. (2019) Total Small Vessel Disease Burden Predicts Functional Outcome in Patients With Acute Ischemic Stroke. Link

Kubota et.al. (2019) Association Between Cerebral Small Vessel Disease and Central Motor Conduction Time in Patients with Vascular Risk. Link

Gutierrez at.al. (2019) Brain arterial dilatation modifies the association between extracranial pulsatile hemodynamics and brain perivascular spaces: the Northern Manhattan Study. Link

Low et.al. (2019) Inflammation and cerebral small vessel disease: A systematic review. Link

Park et.al. (2019) MRI Assessment of Cerebral Small Vessel Disease in Patients with Spontaneous Intracerebral Hemorrhage. Link

Reginold et al. (2019) The efficiency of the brain connectome is associated with cerebrovascular reactivity in persons with white matter hyperintensities. Link

Roth et.al. (2019) Regulator of G-protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke. Link

Shreiber et.al. (2019) Invited Review: The spectrum of age-related small vessel diseases: potential overlap and interactions of amyloid and nonamyloid vasculopathies. Link

Sorond & Gorelick (2019) Brain White Matter: A Substrate for Resilience and a Substance for Subcortical Small Vessel Disease. Link

Wang et.al. (2019) Enlarged Perivascular Spaces and Cerebral Small Vessel Disease in Spontaneous Intracerebral Hemorrhage Patients. Link

Weber et al. (2019) Age and Sex Differences in Ischemic Stroke Treatment in a Nationwide Analysis of 1.11 Million Hospitalized Cases. Link

Wo et.al. (2019) Plasma Klotho concentration is associated with the presence, burden and progression of cerebral small vessel disease in patients with acute ischaemic stroke. Link

Elkin et al. (2019) GlymphVIS: Visualizing Glymphatic Transport Pathways Using Regularized Optimal Transport. Link

 

July

Brutto et.al. (2019) Neuroimaging signatures of cerebral small vessel disease and risk of falls in stroke-free older adults living in rural Ecuador. The Atahualpa Project. Link

Cheng et.al. (2019) Alcohol promotes waste clearance in the CNS via brain vascular reactivity. PDF

Coutts et al. (2019) Rate and Prognosis of Brain Ischemia in Patients With Lower-Risk Transient or Persistent Minor Neurologic Events. Link

Iadecola et. al. (2019) Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel. Link

Pétrault et.al. (2019) Cerebral microbleeds: Beyond the macroscope. Link 

Telgte et al (2019) The Contribution of Acute Infarcts to Cerebral Small Vessel Disease Progression Link

Wei et.al. (2019) A Non-linear Association Between Total Small Vessel Disease Score and Hemorrhagic Transformation After Ischemic Stroke With Atrial Fibrillation and/or Rheumatic Heart Disease. Link

 

June 

Chen et.al. (2019) Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke. Link

Du and Xu (2019). SVN. Neuroimaging studies on cognitive impairment due to cerebral small vessel disease. Access here

Jiang (2019) SVN. MRI and glymphatic system. Access here

Liu et.al. (2019) The global burden of cerebral small vessel disease related to neurological deficit severity and clinical outcomes of acute ischemic stroke after IV rt-PA treatment. Link

Dichgans et al. (2019) Lancet Neurol. Stroke genetics: discovery, biology, and clinical applications

Liang et.al. (2019) Exploring causal pathways linking cerebral small vessel diseases burden to poststroke depressive symptoms with structural equation model analysis. Link 

Gyanwali et. al. (2019) Cerebral Small Vessel Disease and Enlarged Perivascular Spaces-Data From Memory Clinic and Population-Based Settings. Link

 

May

Banerjee et.al. (2019) Effect of small-vessel disease on cognitive trajectory after atrial fibrillation-related ischaemic stroke or TIA. Link

Chen et.al. (2019) Correlation Between Intracranial Arterial Calcification and Imaging of Cerebral Small Vessel Disease. Link

Das et.al. (2019) Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies. Link

Li et.al. (2019) The relationship between blood-brain barrier permeability and enlarged perivascular spaces: a cross-sectional study. Link

Nam et.al. (2019) Left ventricular ejection fraction is associated with small vessel disease in ischaemic stroke patients. Link

Tejada de Rink et.al. (2019) A Single Injection of N-Oleoyldopamine, an Endogenous Agonist for Transient Receptor Potential Vanilloid-1, Induced Brain Hypothermia, but No Neuroprotective Effects in Experimentally Induced Cerebral Ischemia in Rats. Link

Parella et.al. (2019) The Role of Mast Cells in Stroke. Link

Thomas et.al. (2019) Aortic Pulsatility Propagates Intracranially and Correlates with Dilated Perivascular Spaces and Small Vessel Compliance. Link

 

April

Chang et.al. (2019) Interarm Blood Pressure Difference has Various Associations with the Presence and Burden of Cerebral Small-Vessel Diseases in Noncardioembolic Stroke Patients. Link

Staszewski et.al (2019) Cerebral and Extracerebral Vasoreactivity in Patients With Different Clinical Manifestations of Cerebral Small-Vessel Disease: Data From the Significance of Hemodynamic and Hemostatic Factors in the Course of Different Manifestations of Cerebral Small-Vessel Disease Study. Link

 

March

Bouvy et.al. (2019) Microbleeds colocalize with enlarged juxtacortical perivascular spaces in amnestic mild cognitive impairment and early Alzheimer's disease: A 7 Tesla MRI study. Link

Lu et.al. (2019) Extracranial Artery Stenosis Is Associated With Total MRI Burden of Cerebral Small Vessel Disease in Ischemic Stroke Patients of Suspected Small or Large Artery Origins. Link

Pasi et.al. (2019) Cerebral small vessel disease in patients with spontaneous cerebellar hemorrhage. Link

Passiak et.al. (2019) Perivascular spaces contribute to cognition beyond other small vessel disease markers. Link 

Schrimer et al (2019) Spatial Signature of White Matter Hyperintensities in Stroke Patients Link

Yamada et.al. (2019) Location-specific characteristics of perivascular spaces as the brain's interstitial fluid drainage system. Link

Yakushiji et. al. (2019) Distribution of cerebral microbleeds in the East and West. Link

Zhang et.al. (2019) Prevalence and risk factors of perivascular space in the population of Shunyi Study. Link

 

February

Akinyemi et.al. (2019) Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa. Link

Ryu et.al. (2019) Allogeneic adipose-derived mesenchymal stem cell sheet that produces neurological improvement with angiogenesis and neurogenesis in a rat stroke model. Link

 

January 

Feng et.al. (2019) 25-Hydroxy vitamin D level is associated with total MRI burden of cerebral small vessel disease in ischemic stroke patients. Link

Jiang et.al.(2019) Total MRI burden of cerebral vessel disease correlates with the progression in patients with acute single small subcortical strokes. Link

Li et. al. (2019) Incidental findings on brain MRI among Chinese at the age of 55-65 years: the Taizhou Imaging Study. Link

Traylor et. al. (2019). Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226). Link

 

2018


December 

Howe et.al (2018) Fibronectin induces the perivascular deposition of cerebrospinal fluid-derived amyloid-β in aging and after stroke. Link

Li et.al. (2018) Cerebral Small Vessel Disease. Link

Shwarz et.al. (2018) Impact of small vessel disease on severity of motor and cognitive impairment in Parkinson's disease. Link

Yilmaz et.al. (2018) Practical Small Vessel Disease Score Relates to Stroke, Dementia, and Death. Link

November 

Kang et.al. (20180 Association between periodic limb movements during sleep and cerebral small vessel disease. Link

Su et.al. (2018) The consequence of cerebral small vessel disease: Linking brain atrophy to motor impairment in the elderly. PMID: 29956412

October

Chen et.al. (2018) Cerebral small vessel disease: neuroimaging markers and clinical implication. Link

Shi et.al. (2018) Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow. Link

Ombergen et. al. (2018) Brain Tissue-Volume Changes in Cosmonauts. Link

September 

Cuadrado-Godia et.al. (2018) Cerebral Small Vessel Disease: A Review Focusing on Pathophysiology, Biomarkers, and Machine Learning Strategies. Link

August

Feng et.al. (2018) Letter by Feng et al Regarding Article, "Lacunar Infarcts, but Not Perivascular Spaces, Are Predictors of Cognitive Decline in Cerebral Small-Vessel Disease". Link

Hilal et.al. (2018) Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies. Link

Martinez-Ramirez et.al. (2018) Perivascular Spaces Volume in Sporadic and Hereditary (Dutch-Type) Cerebral Amyloid Angiopathy. Link

Yang et.al. (2018) Twenty-four-hour ambulatory blood pressure variability is associated with total magnetic resonance imaging burden of cerebral small-vessel disease. Link

July 

Da Mesquita et al. (2018) Nature. Functional aspects of meningeal lymphatics in aging and Alzheimer's disease. PMID: 30046111

Ghezali et al. (2018) Ann Neurol. Notch3ECD immunotherapy improves cerebrovascular responses in CADASIL mice. PMID: 30014602

Goodman et al. (2018). Brain Behav Immun. Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer's dementia subjects. PMID: 30055243

Harrison et al. (2018). Elife. Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with DTI MRI. PMID: 30063207

Rey and Sarntinoranont (2018). Fluids Barriers CNS. 15(1):20. Pulsatile flow drivers in brain parenchyma and perivascular spaces: a resistance network model study. PMID: 30012159

Ringstad et al. (2018). JCI Insight. 3(13). Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. PMID: 29997300

Zellner et al. (2018) Acta Neuropathol. 136(1):111-125. CADASIL brain vessels show a HTRA1 loss-of-function profile. PMID: 29725820

June 

Faghih and Sharp (2018) Fluids barriers CNS. 15(1):17. Is bulk flow plausible in perivascular, paravascular and paravenous channels? PMID: 29903035

Thomas et al. (2018) Neuroimage 173:25-34. Impact of time-of-day on diffusivity measures of brain tissue derived from diffusion tensor imaging. PMID: 29458189

van Middelaar et. al. (2018) Effect of Antihypertensive Medication on Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis. PMID: 

29739911

 

May 

Alboargothy et al. (2018) Acta Neuropathol. Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brainalong separate periarterial basement membrane pathways. PMID: 29754206

Bower and Hogan (2018) J Mol Med (Berl) 96(5):383-390. Brain drains: new insights into brain clearance pathways from lymphatic biology. PMID: 29610928

Huneau et al. (2018) Ann Clin Transl Neurol 5(7):788-802. Altered dynamics of neurovascular coupling in CADASIL. PMID: 30009197

Nakada and Kwee (2018) Neuroscientist Fluid Dynamics Inside the Brain Barrier: Current Concept of Interstitial Flow, Glymphatic Flow, and Cerebrospinal Fluid Circulation in the Brain. PMID: 29799313

April 

Ratelade et al. (2018) J Pathol. 244(4):408-420. Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke. PMID: 29266233

Taoka et al. (2018) Invest Radiol. Impact of the Glymphatic System on the Kinetic and Distribution of Gadodiamide in the Rat Brain: Observations by Dynamic MRI and Effect of Circadian Rhythm on Tissue Gadolinium Concentrations. PMID: 29652699

March 

Verheggen et al. (2018) Neurosci Biobehav Rev 90:26-33. Interaction between blood-brain barrier and glymphatic system in solute clearance. PMID: 29608988

Huber et al. (2018) Neuroreport. Aquaporin-4 facilitator TGN-073 promotes interstitial fluid circulation within the blood-brain barrier: [17O]H2O JJVCPE MRI study. PMID: 29481527

Benias et al. (2018) Sci Rep. 8(1):4947. Structure and Distribution of an Unrecognized Interstitium in Human Tissues. PMID: 29588511

Abbott et al. (2018) Acta Neuropathol 135(3):387-407. The role of brain barriers in fluid movement in the CNS: is there a 'glymphatic' system? PMID: 29428972

Frosen and Joutel (2018) Cardiovasc Res 114(4):501-512. Smooth muscle cells of intracranial vessels: from development to disease. PMIS: 29351598

February 

Rainey-Smith et al. (2018) Transl Psychiatry 8(1):47. Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden. PMID: 29479071

January

Gakuba et al. (2018) Theranostics 8(3):710-722. General anesthesia inhibits the activity of the "glymphatic system". PMID: 29344300

Eide and Ringstad (2018) J Cereb Blood Flow Metab. Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study. PMID: 29485341

 

2017


October

Absinta et al. (2017) Elife. Human and nonhuman primate meninges harbor lymphatic vessels that can be visualised noninvasively by MRI. PMID: 28971799

September

Sun et al. (2017) Prog Neurobiol. Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases. PMID: 28903061

Yang et al. (2017) Neurol Res. Higher ambulatory systolic blood pressure independently associated with enlarged perivascular spaces in basal ganglia. PMID: 28475469

August 

Ringstad et al. (2017) Brain. Glymphatic MRI in idiopathic normal pressure hydrocephalus. Access here

Smith et al. (2017) Elife. Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4 independent solute transport in rodent brain parenchyma. PMID: 28826498

Nakada et al. (2017) Int J Mol Sci. Aquaporin-4 funcitonality and Virchow-Robin space water dynamics: Physiological model for neurovascular coupling and glymphatic flow. PMID: 28820467

Kapasi et al. (2017) Acta Neuropathol. Impact of multiple pathologies on the threshold for clinically overt dementia. PMID: 28488154

July 

Gottesman et al. (2017) JAMA Neurol. Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort. PMID: 28783817

Machuca-Parra et al. (2017) J Exp Med. Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL. PMID: 28698285

Ding et al. (2017). JAMA Neurol. Large Perivascular Spaces Visible of Magnetic Resonance Imaging, Cerebral Small Vessel Disease Progression, and Risk of Dementia: The Age, Gene/Environment Susceptibility-Reykjavik Study. PMID: 28715552

Rauscher et al. (2017) AJNR Am J Neuroradiol. Cerebral microbleeds: A call for standardized advanced neuroimaging. PMID: 28705820

June 

Blanco et al. (2017) Stroke and Vascular Neurology. Blood pressure gradients in cerebral arteries: a clue to pathogenesis of cerebral small vessel disease. Access here

Rivera-Rivera et al. (2017) J Cereb Blood Flow Metab. 37(6):2149-2158. Changes in intracranial venous blood flow and pulsatility in Alzheimer's disease: A 4D flow MRI study. PMID 27492950

Shenkin et al. (2017) Neuroimage 153:399-409. Improving data availability for brain image biobanking in healthy subjects: Practice-based suggestions from an international multidisciplinary working group. PMID 28232121

May 

Park et al. (2017). Circ Res. Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aß Peptides. PMID 28515043

Chui and Ramirez-Gomez (2017). Neurol Clin. 35(2):295-323. Vascular Contributions to Cognitive Impairment in Late Life PMID: 28410661

Clinical Science themed collection: Small vessels, dementia and chronic disease. Access here  

April 

Bedussi et al. (2017). Sci Rep 7:744. Enhanced interstitial fluid drainage in the hippocampus of spontaneously hypertensive rats PMID: 28389645

Ezzati et al. (2017). J Am Geriatr Soc. Association Between Vascular Pathology and Rate of Cognitive Decline Independent of Alzheimer's Disease Pathology.PMID: 28407205

Holm et al. (2017). J Intern Med. Biomarkers of microvascular endothelial dysfunction predict incident dementia: a population-based prospective study. PMID: 28407377

Joo et al. (2017). Sci Rep 7:464-427. Early neurovascular dysfunction in a transgenic rat model of Alzheimer’s disease. PMID: 28401931  

Joutel and Chabriat (2017) Clin Sci (Lond) 131(8):635-651. Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms. PMID: 28351960

March 

Gutierrez et al. 2017. Am J Neuroradiol Brain Perivascular Spaces as Biomarkers of Vascular Risk: Results from the Northern Manhattan Study. PMID: 28341719

Held et al. 2017 Clin Sci. Vascular basement membrane alterations and β-amyloid accumulations in an animal model of cerebral small vessel disease PMID: 28348005

Zhang et al. 2017. IEEE Trans Biomed Eng. Structured Learning for 3D Perivascular Spaces Segmentation Using Vascular Features.. PMID: 28362579