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Publications related to small vessel disease

 

2019


November

Fultz et. al. (2019) Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep Link

Grifin el.al. (2019) Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury. Link

Liang et.al. (2019) Cerebral Small Vessel Disease Burden Is Associated With Accelerated Poststroke Cognitive Decline: A 1-Year Follow-Up Study. Link

Lo et. al. (2019) Profile of and risk factors for poststroke cognitive impairment in diverse ethno-regional groups. Link

Qu et.al. (2019) Preexisting Cerebral Abnormalities and Functional Outcomes After Acute Ischemic Stroke. Link

Wang et.al. (2019) Understanding the association between psychomotor processing speed and white matter hyperintensity: A comprehensive multi-modality MR imaging study. Link

October

Chung et al (2019) Genome-wide association study of cerebral small vessel disease reveals established and novel loci. Link

Denver et. al. (2019) A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer’s Disease Link

Dobrynina et.al. (2019) Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease. Link

Goldstein et.al. (2019) Cerebral Small Vessel Disease Burden and All-Cause Mortality: Mayo Clinic Florida Familial Cerebrovascular Diseases Registry. Link

Raz et.al. (2019) Possible Empirical Evidence of Glymphatic System on CT after Endovascular Perforations. Link

Villeneuve S (2019) Lifespan Cognitive Reserve—A Secret to Coping With Neurodegenerative Pathology. Link

September

Brutto et.al. (2019) Effect of Heart Rate Variability on the Association Between the Apnea-Hypopnea Index and Cerebral Small Vessel Disease. Link

Duperron et.al. (2019) High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage. Link

Faraco et.al. (2019) Dietary salt promotes cognitive impairment through tau phosphorylation. PDF

August

Hernández-Díaz et.al. (2019) Cerebral Small Vessel Disease Associated with Subclinical Vascular Damage Indicators in Asymptomatic Hypertensive Patients. Link

Huo et. al. (2019) Total Small Vessel Disease Burden Predicts Functional Outcome in Patients With Acute Ischemic Stroke. Link

Kubota et.al. (2019) Association Between Cerebral Small Vessel Disease and Central Motor Conduction Time in Patients with Vascular Risk. Link

Gutierrez at.al. (2019) Brain arterial dilatation modifies the association between extracranial pulsatile hemodynamics and brain perivascular spaces: the Northern Manhattan Study. Link

Low et.al. (2019) Inflammation and cerebral small vessel disease: A systematic review. Link

Park et.al. (2019) MRI Assessment of Cerebral Small Vessel Disease in Patients with Spontaneous Intracerebral Hemorrhage. Link

Reginold et al. (2019) The efficiency of the brain connectome is associated with cerebrovascular reactivity in persons with white matter hyperintensities. Link

Roth et.al. (2019) Regulator of G-protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke. Link

Shreiber et.al. (2019) Invited Review: The spectrum of age-related small vessel diseases: potential overlap and interactions of amyloid and nonamyloid vasculopathies. Link

Sorond & Gorelick (2019) Brain White Matter: A Substrate for Resilience and a Substance for Subcortical Small Vessel Disease. Link

Wang et.al. (2019) Enlarged Perivascular Spaces and Cerebral Small Vessel Disease in Spontaneous Intracerebral Hemorrhage Patients. Link

Wo et.al. (2019) Plasma Klotho concentration is associated with the presence, burden and progression of cerebral small vessel disease in patients with acute ischaemic stroke. Link

July

Brutto et.al. (2019) Neuroimaging signatures of cerebral small vessel disease and risk of falls in stroke-free older adults living in rural Ecuador. The Atahualpa Project. Link

Cheng et.al. (2019) Alcohol promotes waste clearance in the CNS via brain vascular reactivity. PDF

Coutts et al. (2019) Rate and Prognosis of Brain Ischemia in Patients With Lower-Risk Transient or Persistent Minor Neurologic Events. Link

Iadecola et. al. (2019) Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel. Link

Pétrault et.al. (2019) Cerebral microbleeds: Beyond the macroscope. Link 

Telgte et al (2019) The Contribution of Acute Infarcts to Cerebral Small Vessel Disease Progression Link

Wei et.al. (2019) A Non-linear Association Between Total Small Vessel Disease Score and Hemorrhagic Transformation After Ischemic Stroke With Atrial Fibrillation and/or Rheumatic Heart Disease. Link

June 

Chen et.al. (2019) Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke. Link

Du and Xu (2019). SVN. Neuroimaging studies on cognitive impairment due to cerebral small vessel disease. Access here

Jiang (2019) SVN. MRI and glymphatic system. Access here

Liu et.al. (2019) The global burden of cerebral small vessel disease related to neurological deficit severity and clinical outcomes of acute ischemic stroke after IV rt-PA treatment. Link

Dichgans et al. (2019) Lancet Neurol. Stroke genetics: discovery, biology, and clinical applications

Liang et.al. (2019) Exploring causal pathways linking cerebral small vessel diseases burden to poststroke depressive symptoms with structural equation model analysis. Link 

May

Banerjee et.al. (2019) Effect of small-vessel disease on cognitive trajectory after atrial fibrillation-related ischaemic stroke or TIA. Link

Chen et.al. (2019) Correlation Between Intracranial Arterial Calcification and Imaging of Cerebral Small Vessel Disease. Link

Das et.al. (2019) Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies. Link

Li et.al. (2019) The relationship between blood-brain barrier permeability and enlarged perivascular spaces: a cross-sectional study. Link

Nam et.al. (2019) Left ventricular ejection fraction is associated with small vessel disease in ischaemic stroke patients. Link

Tejada de Rink et.al. (2019) A Single Injection of N-Oleoyldopamine, an Endogenous Agonist for Transient Receptor Potential Vanilloid-1, Induced Brain Hypothermia, but No Neuroprotective Effects in Experimentally Induced Cerebral Ischemia in Rats. Link

Parella et.al. (2019) The Role of Mast Cells in Stroke. Link

Thomas et.al. (2019) Aortic Pulsatility Propagates Intracranially and Correlates with Dilated Perivascular Spaces and Small Vessel Compliance. Link

April

Chang et.al. (2019) Interarm Blood Pressure Difference has Various Associations with the Presence and Burden of Cerebral Small-Vessel Diseases in Noncardioembolic Stroke Patients. Link

Staszewski et.al (2019) Cerebral and Extracerebral Vasoreactivity in Patients With Different Clinical Manifestations of Cerebral Small-Vessel Disease: Data From the Significance of Hemodynamic and Hemostatic Factors in the Course of Different Manifestations of Cerebral Small-Vessel Disease Study. Link

March

Bouvy et.al. (2019) Microbleeds colocalize with enlarged juxtacortical perivascular spaces in amnestic mild cognitive impairment and early Alzheimer's disease: A 7 Tesla MRI study. Link

Lu et.al. (2019) Extracranial Artery Stenosis Is Associated With Total MRI Burden of Cerebral Small Vessel Disease in Ischemic Stroke Patients of Suspected Small or Large Artery Origins. Link

Pasi et.al. (2019) Cerebral small vessel disease in patients with spontaneous cerebellar hemorrhage. Link

Passiak et.al. (2019) Perivascular spaces contribute to cognition beyond other small vessel disease markers. Link 

Schrimer et al (2019) Spatial Signature of White Matter Hyperintensities in Stroke Patients Link

Yamada et.al. (2019) Location-specific characteristics of perivascular spaces as the brain's interstitial fluid drainage system. Link

Zhang et.al. (2019) Prevalence and risk factors of perivascular space in the population of Shunyi Study. Link

February

Akinyemi et.al. (2019) Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa. Link

Ryu et.al. (2019) Allogeneic adipose-derived mesenchymal stem cell sheet that produces neurological improvement with angiogenesis and neurogenesis in a rat stroke model. Link

January 

Feng et.al. (2019) 25-Hydroxy vitamin D level is associated with total MRI burden of cerebral small vessel disease in ischemic stroke patients. Link

Jiang et.al.(2019) Total MRI burden of cerebral vessel disease correlates with the progression in patients with acute single small subcortical strokes. Link

Li et. al. (2019) Incidental findings on brain MRI among Chinese at the age of 55-65 years: the Taizhou Imaging Study. Link

 

2018


December 

Howe et.al (2018) Fibronectin induces the perivascular deposition of cerebrospinal fluid-derived amyloid-β in aging and after stroke. Link

Li et.al. (2018) Cerebral Small Vessel Disease. Link

Shwarz et.al. (2018) Impact of small vessel disease on severity of motor and cognitive impairment in Parkinson's disease. Link

Yilmaz et.al. (2018) Practical Small Vessel Disease Score Relates to Stroke, Dementia, and Death. Link

November 

Kang et.al. (20180 Association between periodic limb movements during sleep and cerebral small vessel disease. Link

Su et.al. (2018) The consequence of cerebral small vessel disease: Linking brain atrophy to motor impairment in the elderly. PMID: 29956412

October

Chen et.al. (2018) Cerebral small vessel disease: neuroimaging markers and clinical implication. Link

Shi et.al. (2018) Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow. Link

September 

Cuadrado-Godia et.al. (2018) Cerebral Small Vessel Disease: A Review Focusing on Pathophysiology, Biomarkers, and Machine Learning Strategies. Link

August

Feng et.al. (2018) Letter by Feng et al Regarding Article, "Lacunar Infarcts, but Not Perivascular Spaces, Are Predictors of Cognitive Decline in Cerebral Small-Vessel Disease". Link

Hilal et.al. (2018) Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies. Link

Martinez-Ramirez et.al. (2018) Perivascular Spaces Volume in Sporadic and Hereditary (Dutch-Type) Cerebral Amyloid Angiopathy. Link

Yang et.al. (2018) Twenty-four-hour ambulatory blood pressure variability is associated with total magnetic resonance imaging burden of cerebral small-vessel disease. Link

July 

Da Mesquita et al. (2018) Nature. Functional aspects of meningeal lymphatics in aging and Alzheimer's disease. PMID: 30046111

Ghezali et al. (2018) Ann Neurol. Notch3ECD immunotherapy improves cerebrovascular responses in CADASIL mice. PMID: 30014602

Goodman et al. (2018). Brain Behav Immun. Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer's dementia subjects. PMID: 30055243

Harrison et al. (2018). Elife. Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with DTI MRI. PMID: 30063207

Rey and Sarntinoranont (2018). Fluids Barriers CNS. 15(1):20. Pulsatile flow drivers in brain parenchyma and perivascular spaces: a resistance network model study. PMID: 30012159

Ringstad et al. (2018). JCI Insight. 3(13). Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. PMID: 29997300

Zellner et al. (2018) Acta Neuropathol. 136(1):111-125. CADASIL brain vessels show a HTRA1 loss-of-function profile. PMID: 29725820

June 

Faghih and Sharp (2018) Fluids barriers CNS. 15(1):17. Is bulk flow plausible in perivascular, paravascular and paravenous channels? PMID: 29903035

Thomas et al. (2018) Neuroimage 173:25-34. Impact of time-of-day on diffusivity measures of brain tissue derived from diffusion tensor imaging. PMID: 29458189

van Middelaar et. al. (2018) Effect of Antihypertensive Medication on Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis. PMID: 

29739911

 

May 

Alboargothy et al. (2018) Acta Neuropathol. Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brainalong separate periarterial basement membrane pathways. PMID: 29754206

Bower and Hogan (2018) J Mol Med (Berl) 96(5):383-390. Brain drains: new insights into brain clearance pathways from lymphatic biology. PMID: 29610928

Huneau et al. (2018) Ann Clin Transl Neurol 5(7):788-802. Altered dynamics of neurovascular coupling in CADASIL. PMID: 30009197

Nakada and Kwee (2018) Neuroscientist Fluid Dynamics Inside the Brain Barrier: Current Concept of Interstitial Flow, Glymphatic Flow, and Cerebrospinal Fluid Circulation in the Brain. PMID: 29799313

April 

Ratelade et al. (2018) J Pathol. 244(4):408-420. Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke. PMID: 29266233

Taoka et al. (2018) Invest Radiol. Impact of the Glymphatic System on the Kinetic and Distribution of Gadodiamide in the Rat Brain: Observations by Dynamic MRI and Effect of Circadian Rhythm on Tissue Gadolinium Concentrations. PMID: 29652699

March 

Verheggen et al. (2018) Neurosci Biobehav Rev 90:26-33. Interaction between blood-brain barrier and glymphatic system in solute clearance. PMID: 29608988

Huber et al. (2018) Neuroreport. Aquaporin-4 facilitator TGN-073 promotes interstitial fluid circulation within the blood-brain barrier: [17O]H2O JJVCPE MRI study. PMID: 29481527

Benias et al. (2018) Sci Rep. 8(1):4947. Structure and Distribution of an Unrecognized Interstitium in Human Tissues. PMID: 29588511

Abbott et al. (2018) Acta Neuropathol 135(3):387-407. The role of brain barriers in fluid movement in the CNS: is there a 'glymphatic' system? PMID: 29428972

Frosen and Joutel (2018) Cardiovasc Res 114(4):501-512. Smooth muscle cells of intracranial vessels: from development to disease. PMIS: 29351598

February 

Rainey-Smith et al. (2018) Transl Psychiatry 8(1):47. Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden. PMID: 29479071

January

Gakuba et al. (2018) Theranostics 8(3):710-722. General anesthesia inhibits the activity of the "glymphatic system". PMID: 29344300

Eide and Ringstad (2018) J Cereb Blood Flow Metab. Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study. PMID: 29485341

 

2017


October

Absinta et al. (2017) Elife. Human and nonhuman primate meninges harbor lymphatic vessels that can be visualised noninvasively by MRI. PMID: 28971799

September

Sun et al. (2017) Prog Neurobiol. Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases. PMID: 28903061

Yang et al. (2017) Neurol Res. Higher ambulatory systolic blood pressure independently associated with enlarged perivascular spaces in basal ganglia. PMID: 28475469

August 

Ringstad et al. (2017) Brain. Glymphatic MRI in idiopathic normal pressure hydrocephalus. Access here

Smith et al. (2017) Elife. Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4 independent solute transport in rodent brain parenchyma. PMID: 28826498

Nakada et al. (2017) Int J Mol Sci. Aquaporin-4 funcitonality and Virchow-Robin space water dynamics: Physiological model for neurovascular coupling and glymphatic flow. PMID: 28820467

Kapasi et al. (2017) Acta Neuropathol. Impact of multiple pathologies on the threshold for clinically overt dementia. PMID: 28488154

July 

Gottesman et al. (2017) JAMA Neurol. Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort. PMID: 28783817

Machuca-Parra et al. (2017) J Exp Med. Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL. PMID: 28698285

Ding et al. (2017). JAMA Neurol. Large Perivascular Spaces Visible of Magnetic Resonance Imaging, Cerebral Small Vessel Disease Progression, and Risk of Dementia: The Age, Gene/Environment Susceptibility-Reykjavik Study. PMID: 28715552

Rauscher et al. (2017) AJNR Am J Neuroradiol. Cerebral microbleeds: A call for standardized advanced neuroimaging. PMID: 28705820

June 

Blanco et al. (2017) Stroke and Vascular Neurology. Blood pressure gradients in cerebral arteries: a clue to pathogenesis of cerebral small vessel disease. Access here

Rivera-Rivera et al. (2017) J Cereb Blood Flow Metab. 37(6):2149-2158. Changes in intracranial venous blood flow and pulsatility in Alzheimer's disease: A 4D flow MRI study. PMID 27492950

Shenkin et al. (2017) Neuroimage 153:399-409. Improving data availability for brain image biobanking in healthy subjects: Practice-based suggestions from an international multidisciplinary working group. PMID 28232121

May 

Park et al. (2017). Circ Res. Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aß Peptides. PMID 28515043

Chui and Ramirez-Gomez (2017). Neurol Clin. 35(2):295-323. Vascular Contributions to Cognitive Impairment in Late Life PMID: 28410661

Clinical Science themed collection: Small vessels, dementia and chronic disease. Access here  

April 

Bedussi et al. (2017). Sci Rep 7:744. Enhanced interstitial fluid drainage in the hippocampus of spontaneously hypertensive rats PMID: 28389645

Ezzati et al. (2017). J Am Geriatr Soc. Association Between Vascular Pathology and Rate of Cognitive Decline Independent of Alzheimer's Disease Pathology.PMID: 28407205

Holm et al. (2017). J Intern Med. Biomarkers of microvascular endothelial dysfunction predict incident dementia: a population-based prospective study. PMID: 28407377

Joo et al. (2017). Sci Rep 7:464-427. Early neurovascular dysfunction in a transgenic rat model of Alzheimer’s disease. PMID: 28401931  

Joutel and Chabriat (2017) Clin Sci (Lond) 131(8):635-651. Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms. PMID: 28351960

March 

Gutierrez et al. 2017. Am J Neuroradiol Brain Perivascular Spaces as Biomarkers of Vascular Risk: Results from the Northern Manhattan Study. PMID: 28341719

Held et al. 2017 Clin Sci. Vascular basement membrane alterations and β-amyloid accumulations in an animal model of cerebral small vessel disease PMID: 28348005

Zhang et al. 2017. IEEE Trans Biomed Eng. Structured Learning for 3D Perivascular Spaces Segmentation Using Vascular Features.. PMID: 28362579