Publications from network members since the project began
Publication titles serve as website links that open in a new window.
Kopczak et al. (2023) The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial
Schreiber et al. (2023) Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity
Liebeskind and Wardlaw (2023) Imaging Advances in Stroke: Use of Advanced Neurovascular Imaging or Disruptive Innovation With Artificial Intelligence?
Alzahrani et al (2023) Assessing Brain Tissue Viability on Nonenhanced Computed Tomography After Ischemic Stroke
Thomas and Benveniste (2023) CSF-to-dura gateways
van den Brink et al. (2023) CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI
Persson et al. (2022) Could dexmedetomidine be repurposed as a glymphatic enhancer?
Lahna et al. (2022) Venous Collagenosis as Pathogenesis of White Matter Hyperintensity
Ge et al. (2022) Theory of sleep/wake cycles affecting brain elastography
Zhao et al. (2022) Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain
van den Brink et al. (2022) CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI
Bath et al. (2022) Cilostazol and isosorbide mononitrate for the prevention of progression of cerebral small vessel disease: baseline data and statistical analysis plan for the Lacunar Intervention Trial-2 (LACI-2) (ISRCTN14911850)
Barisano et al (2022) Imaging perivascular space structure and function using brain MRI
Wostyn et al (2022) The effect of long-duration spaceflight on perivascular spaces within the brain
Markus et al. (2022) Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE) A Review
Jochems et al. (2022) Associations of Peak-Width Skeletonized Mean Diffusivity and Post-Stroke Cognition
Bohr et al. (2022) The glymphatic system: Current understanding and modeling
Muratoglu et al (2022) Perspectives on Cognitive Phenotypes and Models of Vascular Disease
Tournissac et al. (2022) Cranial window for longitudinal and multimodal imaging of the whole mouse cortex
Ladrón-de-Guevara et al (2022) Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment
Zhang et al (2022) Could respiration-driven blood oxygen changes modulate neural activity?
Charpak (2022) The (ultra)sound of neurons firing
Kisler & Zlokovic (2022) How the brain regulates its own immune system
Mirza et al (2022) Effects of white matter hyperintensities, neuropsychiatric symptoms, and cognition on activities of daily living: Differences between Alzheimer's disease and dementia with Lewy bodies
Muratoglu et al (2022) Perspectives on Cognitive Phenotypes and Models of Vascular Disease
Wardlaw and Liebeskind (2022) Not Just Blood: Brain Fluid Systems and Their Relevance to Cerebrovascular Diseases
Aydin et al (2022) The oxygen initial dip in the brain of anesthetized and awake mice
Martinez et al (2022) The small HDL particle hypothesis of Alzheimer's disease
Rasmussen et al (2022) Fluid transport in the brain
Winkler et al (2022) A single-cell atlas of the normal and malformed human brain vasculature
Helakari et al (2022) Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations
Wardlaw, Benveniste and Williams (2022) Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical Studies
Wiseman et al (2022) Measuring axial length of the eye from magnetic resonance brain imaging
Benveniste & Nedergaard (2022) Cerebral small vessel disease: A glymphopathy?
Barisano et al (2022) Blood-brain barrier link to human cognitive impairment and Alzheimer's Disease
Huuskonen et al (2022) Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C
McCartney et al (2022) Blood-based epigenome-wide analyses of cognitive abilities
Martikainen et al (2022) TUBE Project: Transport-Derived Ultrafines and the Brain Effects
Zhao & Zlokovic (2021) Can prehospital "plasma supplement" neutralize the systemic storm in severe trauma?
Battistella et al (2021) Not All Lectins Are Equally Suitable for Labeling Rodent Vasculature.
Jiménez-Sánchez et al (2021) Sex differences in cerebral small vessel disease: a systematic review and meta-analysis
Chagnot et al (2021) Magnetic Resonance Imaging of Blood-Brain Barrier permeability in Dementia
Hablitz & Nedergaard (2021) The glymphatic system
Wardlaw et al (2021) Reply to: Rethink the classical view of cerebrospinal fluid production
Benveniste & Nedergaard (2021) Cerebral small vessel disease: A glymphopathy?
Kisler et al (2021) Microglia have a grip on brain microvasculature
Hablitz & Nedergaard (2021) The Glymphatic System: A Novel Component of Fundamental Neurobiology.
Benveniste & Neredgard (2021) Cerebral small vessel disease: A glymphopathy?
Huuskonen et al (2021) On the intersection between systemic infection, brain vascular dysfunction and dementia
Wardlaw et al (2021) A Stroke Is a Stroke, With or Without a Visible Infarct
Procter et al (2021) Interplay between brain pericytes and endothelial cells in dementia
Wardlaw et al (2021) Reply to: Rethink the classical view of cerebrospinal fluid production
Hamilton & Wardlaw (2021) Response to Schroeter ML, Letter, Small vessel disease and social cognition
Wiegertjes et al (2021) Diffusion-weighted imaging lesions and risk of recurrent stroke after intracerebral haemorrhage
Zhu et al (2021) Alzheimer's pathogenic mechanisms and underlying sex difference
Aydin et al (2021) Iliski, a software for robust calculation of transfer functions
Morrison & Valdés Hernández (2021) Systematic Review and Meta-Analysis on incidence and risk of stroke in individuals with long-term exposure to air pollutants
Rasmussen et al (2021) Fluid Transport in the Brain
Sajic et al (2021) High Dietary Fat Consumption Impairs Axonal Mitochondrial Function In Vivo
Boyle et al (2021) Artificial intelligence for molecular neuroimaging
Valdés Hernández (2021) Human Brain Atlases across the lifespan – Anatomical Segmentations
Best et al (2021) Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies
Nikolakopoulou et al (2021) Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A
Zhu et al (2021) Alzheimer's pathogenic mechanisms and underlying sex difference
Valdes-Hernandez et al (2021) Lacunar Stroke Lesion Extent and Location and White Matter Hyperintensities Evolution 1 Year Post-lacunar Stroke
Liebeskind & Wardlaw (2021) Imaging Advances: Acute-on-Chronic Stroke
Ouk et al (2021) The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer's disease: the importance of blood-brain barrier penetration and APOE ε4 carrier status
Clancy et al (2021) Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3
Rajna et al (2021) Cardiovascular brain impulses in Alzheimer's disease
Raghunandan et al (2021) Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection
Sajic et al (2021) High dietary fat consumption impairs axonal mitochondrial function in vivo
Lyden et al (2021) Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation
Gorelick PB, Testai FD, Hankey GJ, Wardlaw JM (2021). "Hankey's Clinical Neurology" (3rd Edition) 20% discount available with a flyer Link
Verdelho et al (2021) Cerebrovascular disease in patients with cognitive impairment: A white paper from the ESO dementia committee – A practical point of view with suggestions for the management of cerebrovascular diseases in memory clinics
Papanastasiou et al (2021) Pharmacokinetic modelling for the simultaneous assessment of perfusion and 18F-flutemetamol uptake in cerebral amyloid angiopathy using a reduced PET-MR acquisition time: Proof of concept
Quick et al (2020). A Vessel for Change: Endothelial Dysfunction in Cerebral Small Vessel Disease
Sargurupremraj et al (2020) Cerebral small vessel disease genomics and its implications across the lifespan
Valdes-Hernandez et al (2020) Brain network reorganisation and spatial lesion distribution in systemic lupus erythematosus
Benveniste et al (2020) The glymphatic system and its role in cerebral homeostasis
Liu et al (2020) Direct Measurement of Cerebrospinal Fluid Production in Mice
[Book chapter] Doubal, [...], Wardlaw (2020). Section 4 Vascular Disease, Chapter 21, Small vessel disease. In Brayne C, Feigin V, Launer L, Logroscino G, eds. Oxford Textbook of Neurologic and Neuropsychiatric Epidemiology. Oxford University Press, Oxford, 2020. DOI link: 10.1093/med/9780198749493.001.0001
Rivas et al (2020) Surface periarterial spaces of the mouse brain are open, not porous
Benveniste et al (2020) Glymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging
Rekik et al (2020) Predictive Intelligence in Medicine (book)
Zhao & Zlokovic (2020) Endothelial Tip Cell Finds Its Way with Piezo1
Zlokovic et al (2020) Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop
Allenbach et al (2020) Immune-mediated necrotizing myopathy: clinical features and pathogenesis
Nedergaard & Goldman (2020) Glymphatic failure as a final common pathway to dementia
Hablitz et al (2020) Circadian control of brain glymphatic and lymphatic fluid flow
Carare et al (2020) Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer’s disease-Opportunities for Therapy
Zhao & Zlokovic (2020) Therapeutic TVs for Crossing Barriers in the Brain
Mestre et al (2020) The Brain's Glymphatic System: Current Controversies
Bernal et al (2020) Examining the relationship between semiquantitative methods analysing concentration-time and enhancement-time curves from dynamic-contrast enhanced magnetic resonance imaging and cerebrovascular dysfunction in small vessel disease
Clancy et al (2020) Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3
Montagne et al (2020) APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline
Montagne et al (2020) APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
Habriat et al (2020) CADASIL: yesterday, today, tomorrow
Blair et. al. (2020) Cerebral small vessel disease: Potential interventions for prevention and treatment; Chapter available in book Stroke in the Older Person
Wardlaw et al (2020) Perivascular spaces in the brain: anatomy, physiology and pathology
Mestre et al (2020) Cerebrospinal fluid influx drives acute ischemic tissue swelling
Hamilton et al. (2020) Cognitive impairments in sporadic cerebral small vessel disease (SVD): a systematic review and meta-analysis of cohorts with stroke, dementia and non-clinical presentations of SVD
Wardlaw et al. (2020) Perivascular spaces in the brain: anatomy, physiology and pathology
Kisler et al. (2020) Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling
Koundal et. al. (2020) Supplementary Information for “Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System”.
Aribisala et. al. (2020) Sleep and brain morphological changes in the eighth decade of life
Mestre et al. (2020) Cerebrospinal fluid influx drives acute ischemic tissue swelling
Ballerini et al (2020). Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936
Ballerini et. al. (2019) Computational quantification of brain perivascular space morphologies: associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936: Perivascular spaces associations
Appleton et al. (2019) Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke
Zhang et al. (2019) Cerebral oxygenation during locomotion is modulated by respiration
Appleton et.al. (2019) Imaging markers of small vessel disease and 'brain frailty' and outcomes in acute stroke
Gattringer et.al. (2019) Predictors of Lesion Cavitation After Recent Small Subcortical Stroke
Habote et.al. (2019) Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments
Valdés Hernández et. al. (2019) Brain Network Measures and Spatial Lesion Distribution in a Sample of 47 Patients with Systemic Lupus Erythematosus (SLE)
Shukuru & Valdés Hernández (2019) Systematic Review of the Literature on Definitions and Characterisation of MS Lesions
El-Tawil et. al. (2019) Observer Agreement on Computed Tomography Perfusion Imaging in Acute Ischemic Stroke
Satizabal et.al. (2019) Genetic architecture of subcortical brain structures in 38,851 individuals
Hachinski et al. (2019) Preventing dementia by preventing stroke: The Berlin Manifesto.
Mortensen et. al. (2019) Impaired Glymphatic Transport in Spontaneously Hypertensive Rats
Appleton et.al. (2019) Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial
Aribisala et al. (2019) Sleep and brain morphological changes in the eighth decade of life
Hachinski et al. (2019) Preventing dementia by preventing stroke: The Berlin Manifesto.
Hillary et. al. (2019) An epigenetic predictor of death captures multi-modal measures of brain health
Wardlaw et. al. (2019) Small vessel disease: mechanisms and clinical implications
Nikolakopoulou et al. (2019) Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss
Blair et.al. (2019) Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial
Nikolakopoulou et. al. (2019) Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss
Thrippleton et.al. (2019) Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations
Debette et. al. (2019) Fourth European stroke science workshop
Wardlaw, Smith and Dichgans (2019) Lancet Neurol. Small vessel disease: mechanisms and clinical implications.
Blair et al. (2019) EClinicalMedicine. Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial
Thrippleton et al. (2019). Alzheimer's and Dementia. Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendation
Mutsaerts et al. (2019). Brain. Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study.
Desmarais et al. (2019) J of Neurology, Neurosurgery& Psychiatry. Therapeutic trial design for frontotemporal dementia and related disorders.
Benveniste et al. (2019) Anesth Analg. Glymphatic System Function in Relation to Anesthesia and Sleep States.
Koundal et al. (2019). Neuroscience. Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI.
Zeng et al. (2019). Cell Rep. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice.
Lindekleiv et al. (2019). Stroke. Percutaneous Vascular Interventions Versus Intravenous Thrombolytic Treatment for Acute Ischemic Stroke.
McHutchison et al. (2019) J of Neurology, Neurosurgery& Psychiatry. Functional, cognitive and physical outcomes 3 years after minor lacunar or cortical ischaemic stroke.
Anderson et al. (2019) Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial.
Boido et al. (2019) Nat Commun Mesoscopic and microscopic imaging of sensory responses in the same animal.
Munk et al. (2019) Cell Rep. PDGF-B Is Required for Development of the Glymphatic System.
Ortiz-Ramon et al. (2019). Comput Med Imaging Graph. Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images.
Valdes Hernandez et al. (2019) Int J Mol Sci. Association between Striatal Brain Iron Deposition, Microbleeds and Cognition 1 Year After a Minor Ischaemic Stroke.
Cox et al. (2019) Eur Heart J. Associations between vascular risk factors and brain MRI indices in UK Biobank.
Georgakis et al. (2019) WMH and long-term outcomes in ischemic stroke: A systematic review and meta-analysis.
Duchesne et al. (2019) The Canadian Dementia Imaging Protocol: Harmonizing National Cohorts.
Rungta et al. (2019) Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia.
Sagare et al. (2019). Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits.
Thrippleton et al. (2019). MRI Relaxometry for Quantitative Analysis of USPIO Uptake in Cerebral Small Vessel Disease.
Appleton et al. (2019) Effect of Glyceryl Trinitrate on Hemodynamics in Acute Stroke.
Sweeney et al. (2019). Alzheimers Dement. Vascular dysfunction-The disregarded partner of Alzheimer's disease.
Sweeney et al. (2019). Physiol Rev. Blood-Brain Barrier: From Physiology to Disease and Back.
Demiral et al. (2019) Neuroimage. Apparent diffusion coefficient changes in human brain during sleep - Does it inform on the existence of a glymphatic system?
Ramos et al. (2019) Methods Mol Biol. Cisterna Magna Injection in Rats to Study Glymphatic Function.
Rehm et al. (2019) Alzheimers Res Ther. Alcohol use and dementia: a systematic scoping review. PMID: 30611304
Dey et al. (2019). Neurobiol Aging. Cognitive hereterogeneity among community-dwelling older adults with cerebral small vessel disease. PMID: 30875655
Mikhael et al. (2019) Manually-parcellated gyral data accounting for all known anatomical variability.
Davis et al. (2018). Am J Pathol. A Novel Transgenic Rat Model of Robust Cerebral Microvascular Amyloid with Prominent Vasculopathy.
Mestre et al. (2018) Elife. Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
Plog et al. (2018) JCI Insight. Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.
Yu et al. (2018) Transl Stroke Res. Soluble Epoxide Hydrolase-Derived Linoleic Acid Oxylipins in Serum Are Associated with Periventricular White Matter Hyperintensities and Vascular Cognitive Impairment.
Malik et al. (2018) Neurorehabil Neural Repair. Subcortical Brain Involvement Is Associated With Impaired Performance on the Psychomotor Vigilance Task After Minor Stroke.
Bergeron et al. (2018). Ann Neurol. Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.
Mestre et al. (2018) Nat Commun. Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.
Rasmussen, Mestre and Nedergaard (2018). Lancet Neurology. 17(11):1016-1024. The glymphatic pathway in neurological disorders. Access here.
Sweeney et al. (2018) Nat Neurosci. The role of brain vasculature in neurodegenerative disorders.
Alhusaini et al. (2018) Association between carotid atheroma and cerebral cortex structure at age 73 years.
Blair et al. (2018). Tolerability, Safety and Intermediary Pharmacological Effects of Cilostazol and Isosorbide Mononitrate, Alone and Combined, in Patients with Lacunar Ischaemic Stroke: The LACunar Intervention-1 (LACI-1) Trial
Brown et. al. (2018) Understanding the role of the perivascular space in cerebral small vessel disease
Sapkota et al. (2018) Alzheimers Res Ther Clinical dementia severity associated with ventricular size is differentially moderated by cognitive reserve in men and women.
Elkin et al. (2018) Med Image Comput Comput Assist Interv. GlymphVIS: Visualizing Glymphatic Transport Pathways Using Regularized Optimal Transport.
Madru et al. (2018) Cancer Biother Radiopharm. Simultaneous Preclinical Positron Emission Tomography-Magnetic Resonance Imaging Study of Lymphatic Drainage of Chelator-Free 64Cu-Labeled Nanoparticles.
Pelligrini et al. (2018) Alzheimers Dement. Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review.
Sweeney and Zlokovic (2018). Nature News and Views. 560(7717): 172-174. A lymphatic waste-disposal system implicated in Alzheimer's disease. PMID: 30076374
Zukotynski et al. (2018). AJR Am J Roentgenol. 211(2):246-259. PET/CT of Dementia. PMID: 29949415
Gibson et al. (2018) Post-mortem magnetic resonance imaging in patients with suspected prion disease: Pathological confirmation, sensitivity, specificity and observer reliability. A national registry.
Lipsman et al. (2018) Nat commun. Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound.
Aalling et al. (2018). Curr Neurol Neurosci Rep 18(9):57. Cerebral Metabolic Changes During Sleep. PMID: 30014344
Backhouse et al. (2018) PLoS One. 13(7):e0200525. Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: A systematic review and meta-analysis. PMID: 30011299
Benveniste et al. (2018). Genontology 11:1-14. The glymphatic system and waste clearance with brain aging. PMID: 29996134
Freedman et al. (2018) Alzheimers Res Ther 10(1):65. The Toronto Cognitive Assessment (TorCA): normative data and validation to detect amnestic mild cognitive impairment. PMID: 30021658
Griffin et al. (2018) Blood. 132(2):159-169. Activated protein C, protease activated receptor 1, and neuroprotection. PMID: 29866816
Jian et al (2018) Stroke. Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging. PMID: 30002152
Rajani et al. (2018) Science translational medicine. Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Access here
Wardlaw (2018) Stroke. 49(7):1770-1775. William M. Feinberg Award for Excellence in Clinical Stroke: Small Vessel Disease; a Big Problem, But Fixable. PMID: 29895535
Wiseman et al. (2018) Lupus. 27(8):1329-1337. Cognitive function, disease burden and the structural connectome in systemic lupus erythematosus. PMID: 29722629
Zellner et al. (2018) CADASIL brain vessels show a HTRA1 loss-of-function profile.
Ida et al. (2018) Br J Anaesth 120(6):1245-1254. Protection of cerebral microcirculation, mitochondrial function, and electrocortical activity by small-volume resuscitation with terlipressin in a rat model of harmorrhagic shock. PMID: 29793592
Kisler et al. (2018) Nat Protoc 13(6):1377-1402. In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain. PMID: 29844521
Lam et al. (2018) Sci Rep 8(1):9480. Variability in stroke motor outcome is explained by structural and functional integrity of the motor system. PMID: 29930399
Pottier et al. (2018) Lancet Neurol. 17(6):548-558. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration adn GRN mutations: a genome-wide association study. PMID: 2972492
Bernhardt et al. (2018) Stroke. 49(5):e174-199. Advances in Stroke 2017. PMID: 29669874
Brown et al. (2018) Cardiovasc Res. Understanding the role of the perivascular space in cerebral small vessel disease. PMID: 29726891
Cox et al. (2018) Neurobiol of Aging. Longitudinal serum S100β and brain ageing in the Lothian Birth Cohort 1936.
Fujioka et al. (2018) Ann N Y Acad Sci. The effects of music-supported therapy on motor, cognitive, and psychosocial functions in chronic stroke. PMID: 29797585
Loos et al. (2018) Stroke. 49(5):1183-1188. Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging. PMID: 29567763
Saeed et al. (2018) Alzheimers Dement. APOE-ε4 associates with hippocampal volume, learning, and memort across the spectrum of Alzheimer's disease and dementia with Lewy bodies. PMID: 29782824
Wong et al. (2018) Int J Geriatr Psychiatry. 33(5):729-734. Converting MMSE to MoCA and MoCA 5-minute protocol in an educationally heterogeneous sample with stroke or transient ischemic attack. PMID: 29292529
Xavier et al. (2018) J Vis Exp. Cannula Implantation into the Cisterna Magna of Rodents. PMID: 29889209
Bailey et al. (2018) Clin Sci (Lond). Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. PMID: 29632138
Dawe et al. (2018) J Gerontol A Biol Sci Med Sci. 73(5):636-642. Association Between Quantitative Gait and Balance Measures and Total Daily Physical Activity in Community-Dwelling Older Adults. PMID: 28957994
Horsburgh et al. (2018) Clin Sci (Lond). 132(8):851-868. Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. PMID: 29712883
Lewis et al. (2018). Neuroimage. 176:22-28. Widespread associations between trait conscientiousness and thickness of brain cortical regions. PMID: 29665419
Makaryus et al. (2018) Anesthesiology. Noninvasive Tracking of Anesthesia Neurotoxicity in the Developing Rodent Brain. PMID: 29688900
Ratelade et al. (2018) J Pathol. 244(4):408-420. Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke. PMID: 29266233
Shokri-Kojori et al. (2018) Proc Natl Acad Sci USA 115(17):4483-4488. β-Amyloid accumulation in the human brain after one night of sleep deprivation. PMID: 29632177
Berezuk et al. (2018) Int J Geriatr Psychiatry. 33(3):517-522. Managing money matters: Managing finances is associated with functional independence in MCI. PMID: 29076183
Ferguson et al. (2018) J Stroke Cerebrovasc Dis. Visual Rating Scales of White Matter Hyperintensities and Atrophy: Comparison of Computed Tomography and Magnetic Resonance Imaging. PMID: 29576397
Makin et al. (2017) European Stroke Journal. The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke. Access here
McGrory et al. (2018) Transl Vis Sci Technol. 7(2):12. Towards Standardization of Quantitative Retinal Vascular Parameters: Comparison of SIVA and VAMPIRE Measurements in the Lothian Birth Cohort 1936. PMID: 29600120
Montagne et al. (2018) Nat Med. 24(3):326-337. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. PMID: 29400711
Rodrigues et al. (2018) Lancet Neurol. 17(3):232-240. The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study. PMID: 29331631
Skrobot et al. (2018) Alzheimers Dement. 14(3):280-292. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study. PMID: 29055812
Sweeney et al. (2018) Nat Rev Neurol. 14(3):133-150. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. PMID: 29377008
Wilcox et al. (2018) Intern Med J. Sleep on the ward in intensive care unit survivors: a case series of polysomnography. PMID: 29521453
Ballerini et al. (2018) Sci Rep. 8(1):2132. Perivascular spaces segmentation in brain MRI using optimal 3D filtering. PMID: 29391404
Desmarais et al. (2018). Int Psychogeriatr. 30(2):197-207. Social inappropriateness in neurodegenerative disorders. PMID: 28689508
Jaswal et al. (2018) Neurobiol Aging. 66:23-31. Reduced substantia innominata volume mediates contributions of microvascular and macrovascular disease to cognitive deficits in Alzheimer's disease. PMID: 29505952
Lundgaard et al. (2018) Sci Rep. 8(1):2246. Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. PMID: 29396480
Mortby et al. (2018) Int Psychogeriatr. 30(2):171-175. Dementia clinical trial implications of mild behavioral impairment. PMID: 29448970
Ritchie et al. (2018). Neurobiol Aging. 62:146-158. Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume. PMID: 29149632
Sajic et al. (2018) J Neuroinflammation. 15(1):61. Mitochondrial damage and "plugging" of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation. PMID: 29486771
Santiago et al. (2018) Int J Geriatr Psychiatry. 33(2):279-287. Subcortical hyperintensities in the cholinergic system are associated with improvements in executive function in older adults with coronary artery disease undergoing cardiac rehabilitation. PMID: 28474775
Swardfager et al. (2018). Neurology. 90(8):e673-682. The effect of white matter hyperintensities on verbal memory: Mediation by temporal lobe atrophy. PMID: 29374101
Thrippleton et al.(2018) Int J Stroke. 13(2):195-206. Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing. PMID: 28933655
Wiseman et al. (2018). Hum Brain Mapp. 39(2):622-632. Cognitive abilities, brain white matter hyperintensity volume, and structural network connectivity in older age. PMID: 29139161
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