Dr Abhay's current research in the Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, is focused on gaining a better understanding of the causes of blood-brain barrier (BBB) dysfunction and identifying CSF / plasma biomarkers of BBB breakdown in chronic neurodegenerative disorders. Vascular contribution to neurodegenerative and other CNS disorders is increasingly recognized. Identifying early biomarkers associated with BBB dysfunction and developing potential vasculoprotective therapeutic approaches could help delay or prevent cognitive decline in Alzheimer’s disease.


Key publications

Sagare AP, Sweeney MD, Nelson AR, Zhao Z, Zlokovic BV. Prion Protein Antagonists Rescue Alzheimer’s Amyloid-β-Related Cognitive Deficits. Trends Mol Med 2019;25:74–6. PMID: 30661727.

Publication link: www.ncbi.nlm.nih.gov/pubmed/?term=30661727

Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. J Exp Med 2019;216:279–93. PMID: 30647119

Publication link: www.ncbi.nlm.nih.gov/pubmed/?term=30647119


Related links

Dr Sagare Abhay - list of publication (PubMed)


University of Southern California