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Professor Mack is an Associate Professor of Neurosurgery and a faculty member of the Neuroscience Graduate Program at University of Southern California. His area of clinical focus is endovascular and surgical management of patients with cerebrovascular disease.

Professor Mack attended Columbia University, College of Physicians and Surgeons, where he graduated from medical school and completed Neurosurgical residency training. During residency, he performed a post-doctoral cerebrovascular research fellowship. Following residency, he completed an Interventional Neuroradiology/ Neuroendovascular Surgery fellowship at UCLA.

Professor Mack's translational science laboratory efforts focus on the role of inflammation and oxidative stress in the setting of stroke and cerebrovascular disease, with a particular interest in the joint influence of nanoparticulate matter exposure and chronic cerebral hypoperfusion. Studies examine white matter injury and neurocognitive changes in the setting of inflammation and carotid stenosis.

Professor Mack is a Principal Investigator for the following research projects:

  • "Neurotoxicity of Airborne Particles: Role of Chronic Cerebral Hypoperfusion", to examine the joint effects of particulate matter exposure and chronic cerebral hypoperfusion on white matter injury and neurocognitive deficits (funded by NIH / NIEHS) 

  • "Urban Air Pollution and Cerebral Hypoperfusion: Aginig and Sex Influences", to examine the age and sex effects of air pollution and chronic cerebrla hypoperfusion on white matter injury, neurocognition, and signatures of Alzheimer’s Disease (funded by NIH/ NIA)

  • USC Neurosurgery Research Education Program, to train and mentor Neurosurgery residents and fellows in basic, clinical and translational research (funded by NIH/ NINDS)

  • An Endovascular Device for Transvenous Electroencephalography: Provost New Direction Grant (funded by University of Southern California; co-PI Meng)


Key publications

Liu Q, Radwanski R, Babadjouni R, Patel A, Hodis DM, Baumbacher P, Zhao Z, Zlokovic B, Mack WJ. Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum. J Cereb Blood Flow Metab. 2017 Jan 1:27. PMID: 29192539

Publication link: www.ncbi.nlm.nih.gov/pubmed/?term=29192539

Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV.Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018. PMID: 29400711

Publication link: www.ncbi.nlm.nih.gov/pubmed/?term=29400711


Related links

Professor William Mack - list of publications (PubMed)

University of Southern California